Therapeutic Application of Pineapple Protease (Bromelain): A Review

Authors

  • Bitange Nipa Tochi Department of Food Science and Engineering, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China
  • Zhang Wang Department of Food Science and Engineering, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China
  • Shi - Ying Xu Department of Food Science and Engineering, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China
  • Wenbin Zhang Department of Food Science and Engineering, School of Food Science and Technology, Jiangnan University, Wuxi 214122, PR China

DOI:

https://doi.org/10.3923/pjn.2008.513.520

Keywords:

Bromelain, inflammation, pineapple, proteinases

Abstract

Bromelain (EC 3.4.22.32) is a crude extract from the pineapple (Ananas comosus) plant that contains, among other components various closely related proteinases (stem bromelain, fruit bromelain, comosain and ananain) demonstrating both in vitro and in vivo several therapeutic properties including malignant cell growth, thrombus formation, inflammation, control of diarrhoea, dermatological and skin debridement among others. Bromelain also contains peroxidase, acid phosphatase, several protease inhibitors and organically bound calcium and remains stable over a wide range of pH 2 to 9. Available evidence indicates bromelain is well absorbed orally with its therapeutic effects being enhanced in a dose dependent manner. It has been demonstrated to be safe and an effective food supplement. However, all the mechanisms of its action remain unresolved.

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Published

15.06.2008

Issue

Vol. 7 No. 4 (2008)

Section

Review

License

Copyright (c) 2008 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

1.
Tochi BN, Wang Z, Xu S-Y, Zhang W. Therapeutic Application of Pineapple Protease (Bromelain): A Review. Pak. J. Nutr. [Internet]. 2008 Jun. 15 [cited 2025 Jul. 8];7(4):513–520. Available from: https://pjnonline.org/pjn/article/view/679