The Effect of Phyllantus emblica Linn on Type - II Diabetes, Triglycerides and Liver - Specific Enzyme

Authors

  • Viqar Sultana Biotechnolgy and Drug Development Laboratory, Department of Biochemistry, University of Karachi, Karachi - 75720, Pakistan
  • Shamim A. Qureshi Department of Biochemistry, University of Karachi, Karachi - 75720, Pakistan
  • Warda Asad Department of Biochemistry, Jinnah University for Women, Karachi, Pakistan

DOI:

https://doi.org/10.3923/pjn.2009.125.128

Keywords:

Alanine transaminase, aqueous fruit extract of P. emblica, cholesterol, triglycerides, type-II diabetes

Abstract

The effect of aqueous fruit extract of Phyllanthus emblica Linn was studied on type-II diabetes, triglycerides (TG) and liver-specific enzyme, alanine transaminase (ALT). Our study showed that aqueous fruit extract, in a dose of 200mg/kg body weight, significantly decreased the blood glucose level after its intra-peritoneal administration in alloxan-induced diabetic rats (p<0.05). Almost similar decreased in glucose level was also observed by chlorpropamide, a known antidiabetic drug in a dose of 84 mg/kg. The aqueous extract also induced hypotriglyceridemia by decreasing TG levels at 0, 1, 2 and 4 hours in diabetic rats (p<0.05). In addition, the extract was also found to improve liver function by normalizing the activity of liver-specific enzyme alanine transaminase (ALT).

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Published

15.01.2009

Issue

Vol. 8 No. 2 (2009)

Section

Research Article

License

Copyright (c) 2009 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Sultana, V., Qureshi, S. A., & Asad, W. (2009). The Effect of Phyllantus emblica Linn on Type - II Diabetes, Triglycerides and Liver - Specific Enzyme. Pakistan Journal of Nutrition, 8(2), 125–128. https://doi.org/10.3923/pjn.2009.125.128

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