Ziziphus mauritiana Fruit Extract Inhibits Carbon Tetrachloride-induced Hepatotoxicity in Male Rats

Authors

  • D. Dahiru Department of Biochemistry, Federal University of Technology, P.M.B. 2076, Yola, Adamawa State, Nigeria
  • D.N. Mamman Department of Biochemistry, Federal University of Technology, P.M.B. 2076, Yola, Adamawa State, Nigeria
  • H.Y. Wakawa Department of Biochemistry, Federal University of Technology, P.M.B. 2076, Yola, Adamawa State, Nigeria

DOI:

https://doi.org/10.3923/pjn.2010.990.993

Keywords:

CCl4, hepatotoxicity, protection, ziziphus mauritiana fruit

Abstract

The aqueous extract of Ziziphus mauritiana fruit (Zm) was evaluated for its protective activity against CCl4-induced liver damage. 250, 500 mg/kg bw of Zm fruit extract or 100 mg/kg silymarin (standard) were administered to different groups of rats prior to CCl4 administration. Both 250 and 500 mg/kg bw of Zm fruit extract significantly (p<0.05) reduced (dose dependently) the levels of enzymes and non-enzymes markers of tissue damage when compared to rats given CCl4 only. These findings were supported by liver histology and suggest that Zm fruit possessed reach hepatoprotective principles that inhibited the toxicity of CCl4 against the liver.

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Published

15.09.2010

Issue

Vol. 9 No. 10 (2010)

Section

Research Article

License

Copyright (c) 2010 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

1.
Dahiru D, Mamman D, Wakawa H. Ziziphus mauritiana Fruit Extract Inhibits Carbon Tetrachloride-induced Hepatotoxicity in Male Rats. Pak. J. Nutr. [Internet]. 2010 Sep. 15 [cited 2025 Jul. 27];9(10):990–993. Available from: https://pjnonline.org/pjn/article/view/1307