Effect of Acalypha wilkesiana on Activities of Some Liver Function Enzymes and Body Weight of Normal Rabbits

Authors

  • Omage Kingsley Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Erifeta O. Georgina Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Josiah J. Sunday Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Uhunmwangho S. Esosa Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Nwangwu C. Spencer Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Njoya K. Helen Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria
  • Asuk A. Agbor Department of Biochemistry, Igbinedion University, Okada, Edo State, Nigeria

DOI:

https://doi.org/10.3923/pjn.2011.552.554

Keywords:

Acalypha wilkesiana, aqueous concoction, diagnostic enzymes, weight reduction

Abstract

The effects of Acalypha wilkesiana leaves on serum ALT and AST activities and body weight of normal rabbits were investigated. Oral administration of the leaf, in the form of decoction prepared by mixing 5 g of air-dried powdered leaves in 10 ml distilled water, at a dose of 1 g/kg body weight for a period of 8 and 15 days, caused a significant increase (p<0.05) in the activities of serum ALT and a significant decrease (p<0.05) in AST activities in normal rabbits. The treatment also led to a significant reduction (p<0.05) on the body weight of the experimental animals. This effect of the plant is a reflection of the relative safety of the plant in the management of hypertension and its possible use as a weight reduction therapy.

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Published

15.05.2011

Issue

Vol. 10 No. 6 (2011)

Section

Research Article

License

Copyright (c) 2011 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Kingsley, O., Georgina, E. O., Sunday, J. J., Esosa, U. S., Spencer, N. C., Helen, N. K., & Agbor, A. A. (2011). Effect of Acalypha wilkesiana on Activities of Some Liver Function Enzymes and Body Weight of Normal Rabbits. Pakistan Journal of Nutrition, 10(6), 552–554. https://doi.org/10.3923/pjn.2011.552.554