Effect of Cinnamon (Cinnamomum cassia) on Blood Sugar, Lipid Profile and Liver Function of Male Wistar Rats
DOI:
https://doi.org/10.3923/pjn.2019.989.996Keywords:
Blood sugar, cinnamon, lipid profile, liver, non-communicable diseasesAbstract
Background and Objective: Cinnamon is one of the most important spices that are highly valued for their health benefits. Thus, the study aimed at determining the effect of cinnamon on blood sugar, lipid profile and liver function of male wistar rats. Materials and Methods: Cinnamon sticks were sorted, washed, dried at 60°C and milled to powdery form. Fifteen male wistar rats were grouped into three. Group A (control) was fed regular rat feed, while group B was fed regular rat feed with 5% concentration of cinnamon and group C was given regular rat feed with 2.5% cinnamon. The weight and fasting blood sugar level of the rats were taken at baseline. Weekly weight gain, daily feed and water intake were recorded. Fasting blood sugar was determined every two weeks during the experiment. At the end of the experiment at fourth week, blood samples were collected for determination of the plasma glucose concentration, glycosylated haemoglobin (HbA1c), liver function and for lipid profile test. Liver samples were harvested for histopathology. Results: Cinnamon had blood sugar lowering effect at both concentrations of 2.5 and 5%. However, there was no significant difference in glycosylated haemoglobin, while plasma glucose concentration was lower in rats fed cinnamon. Cinnamon increased the high density lipoprotein (HDL) level but had negligible effect on other lipid profile parameters. There was no significant effect on aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Also the liver histopathology of rats fed 2.5% cinnamon and that of the control were comparable while that of rats fed 5% cinnamon revealed a deposition of plagues, enlarged sinusoids and hepatocyte with mild necrotic features. Conclusion: Cinnamon powder at the concentrations used, had lowering effect on the blood sugar with positive effect on the lipid profile and mild to adverse effect on the liver of normal wistar rats.
References
WHO., 2003. The world health report 2003-shaping the future. https://www.who.int/whr/2003/en/whr03_en.pdf.
Global Health Watch, 2016. Prevention and control of noncommunicable diseases. https://www.ghwatch.org/who-watch/wha64/ncds.
Promois, J. and J.D. Klein, 2012. Noncommunicable diseases in children and adolescents. Paediatrics, 130: 379-382.
Abegunde, D.O., C.D. Mathers, T. Adam, M. Ortegon and K. Strong, 2007. The burden and costs of chronic diseases in low-income and middle-income countries. Lancet, 370: 1929-1938.
WHO., 2018. Noncommunicable Diseases Country Profiles 2018. World Health Organization, Geneva, Switzerland, ISBN: 9789241514620, Pages: 223.
Ranasinghe, P., S. Perera, G. Mangala, A. Eranga and G. Nuwan et al., 2012. Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model. Pharmacogn. Res., 4: 73-79.
WHO., 2010. Background paper: Non-communicable diseases in low- and middle-income countries. Regional High-Level Consultation, Tehran, October 25-26, 2010. World Health Organization, Geneva.
Qin, B., M. Nagasaki, M. Ren, G. Bajotto, Y. Oshida and Y. Sato, 2003. Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabetes Res. Clin. Pract., 62: 139-148.
Lee, H.S., B.S. Kim and M.K. Kim, 2002. Suppression effect of Cinnamomum cassia bark-derived component on nitric oxide synthase. J. Agric. Food Chem., 50: 7700-7703.
Cao, H., D.J. Graves and R.A. Anderson, 2010. Cinnamon extract regulates glucose transporter and insulin-signaling gene expression in mouse adipocytes. Phytomedicine, 17: 1027-1032.
Beji, R.S., S. Khemir, W.A. Wannes, K. Ayari and R. Ksouri, 2018. Antidiabetic, antihyperlipidemic and antioxidant influences of the spice cinnamon (Cinnamomum zeylanicumon) in experimental rats. Braz. J. Pharm. Sci., Vol. 54, No. 2.
Roche Diabetes Care, 2016. User’s manual blood glucose meter. http://www.roche.de/diagnostics/index.htm.
Randox Laboratories Ltd., 2019. Randox reagents. https://www.randox.com/wp-content/uploads/delightful-downloads/2019/06/Reagents-brochure-LT314-JUN19.pdf.
Spectrum, 2018. Glycosylated hemoglobin (GHb). http://www.spectrum-diagnostics.com/data/GLYCOSYLATED_HEMOGLOBIN_KIT.pdf.
Sheehan, D.C. and B.B. Hrapchak, 1987. Theory and Practice of Histotechnology. 2nd Edn., Battelle Press, Columbus, OH., USA., ISBN: 9781574770674, Pages: 481.
Ahmad, R.A., H. Serati-Nouri, F.A.A. Majid, M.R. Sarmidi and R.A. Aziz, 2015. Assessment of potential toxicological effects of cinnamon bark aqueous extract in rats. Int. J. Biosci. Biochem. Bioinf., 5: 36-44.
Bernado, M.A., M.L. Silva, E. Santos, M. Moncada and J. Brito et al., 2015. Effect of cinnamon tea on postprandial glucose concentration. J. Diabetes Res., Vol. 2015.
Yaghmoor, S.S. and S.M. Khoja, 2010. Effect of cinnamon on plasma glucose concentration and the regulation of 6-phosphofructo-1-kinase activity from the liver and small intestine of streptozotocin induced diabetic rats. J. Biol. Sci., 10: 761-766.
Vanschoonbeek, K., B.J.W. Thomassen, J.M. Senden, W.K.W.H. Wodzig and L.J.C. van Loon, 2006. Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J. Nutr., 136: 977-980.
Rahman, S., H. Begum, Z. Rahman, F. Ara, M.J. Iqbal and A.K.M. Yousuf, 2013. Effect of cinnamon (Cinnamomum cassia) as a lipid lowering agent on hypercholesterolemic rats. J. Enanm Med. Coll., 3: 94-98.
Bodeker, G. and F. Kronenberg, 2002. A public health agenda for traditional, complementary and alternative medicine. Am. J. Public Health, 92: 1582-1591.
Sharp, P.E. and M.C. La Regina, 1998. The Laboratory Rats. CRC Press, New York.
Anand, P., K.Y. Murali, V. Tandon, P.S. Murthy and R. Chandra, 2010. Insulinotropic effect of cinnamaldehyde on transcriptional regulation of pyruvate kinase, phosphoenolpyruvate carboxykinase and GLUT4 translocation in experimental diabetic rats. Chemico-Biol. Interact., 186: 72-81.
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