Research Article Open Access

Toxicity of Anagallis arvensis Plant

Authors

CORRESPONDING AUTHOR
S.I. Al-Sultan
Department of Public Health and Animal Husbandry, College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 11647, AI-Ahsa 31982, Saudi Arabia
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Y.A. Hussein
Department of Clinical Studies, College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 11647, AI-Ahsa 31982, Saudi Arabia
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A. Hegazy
Department of Pathology, College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 11647, AI-Ahsa 31982, Saudi Arabia
Published on: April 15, 2003
DOI 10.3923/pjn.2003.116.122
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Abstract

Sixty adult rats of both sexes were used for determination of LD50 of Anagallis arvensis. Other eighteen rats were used for repeated successive dose for determination of blood picture, kidney function and histopathological changes associated with A. arvensis toxicosis (1/5 and 1/10 LD50) IP for 15 days. The LD50 was 10.718 mg/kg.b.wt. of alcoholic extract of A. arvensis. The clinical signs included anorexia, restlessness, diarrhea, thirst, difficult breathing, tremors and ended by coma and death. Hematologically, there were a significant reduction in PCV%, Hb concentration and RBCs count of the intoxiced rats. Concerning kidney function tests, there were a significant increase in urea and creatinine level of the intoxicated rats. Pathologically, the lesions were primarily confined to the urinary system.

Keywords:

Anagallis arvensis, Rat, Alcohlic extracts, Saudi Arabia

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Copyright (c) 2003 Asian Network for Scientific Information

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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How to Cite

Al-Sultan, S., Hussein, Y., & Hegazy, A. (2003). Toxicity of Anagallis arvensis Plant. Pakistan Journal of Nutrition, 2(3), 116-122. https://doi.org/10.3923/pjn.2003.116.122
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