Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats

Authors

  • Aida Zarfeshani Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • Mohd Sokhini Abd Mutalib Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  • Huzwah Khaza'ai Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia

DOI:

https://doi.org/10.3923/pjn.2012.21.26

Keywords:

High fructose diet, hyperglycemia, inflammatory biomarkers, sprague-dawley rats

Abstract

It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fructose diet-induced rats. The HFD was induced through drinking water in 21% (w/v) concentration among male Sprague-Dawley rats. The high fructose diet administration was unable to induce hyperglycemia, hypertriglyceridemia or any classic inflammatory markers. Also, no histological inflammation was observed. It was concluded that healthy Sprague-Dawley rats fed high fructose diet for 2.5 months could not develop signs of diabetes mellitus type 2.

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Published

15.12.2011

Issue

Vol. 11 No. 1 (2012)

Section

Research Article

License

Copyright (c) 2012 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Zarfeshani, A., Abd Mutalib, M. S., & Khaza'ai, H. (2011). Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats. Pakistan Journal of Nutrition, 11(1), 21–26. https://doi.org/10.3923/pjn.2012.21.26