Research Article Open Access

Effect of Vitamin D Supplementation in a Sample of Type 2 Diabetes Patients from Karak Governorate in Jordan

Authors

Fadwa Ghazi Hammouh
Department of Nutrition and Food Technology, Faculty of Agriculture, Mu`tah University, Karak, Jordan
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CORRESPONDING AUTHOR
Salma Khalil Tukan
Department of Nutrition and Food Technology, Faculty of Agriculture, University of Jordan, Amman, Jordan
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Hamed Rabah Takruri
Department of Nutrition and Food Technology, Faculty of Agriculture, University of Jordan, Amman, Jordan
Published on: January 15, 2015
DOI 10.3923/pjn.2015.75.79
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Abstract

Vitamin D status of type 2 diabetes mellitus (T2DM) patients in Karak Governorate in Jordan was assessed and the relationship between vitamin D supplementation and blood glucose was found. The study recruited thirty three confirmed T2DM subjects (19 males and 14 females) with deficient or insufficient vitamin D status. They were given a supplement of 2000 IU of vitamin D3 daily for 1 month. Fasting blood samples were taken before and after supplementation. Serum levels of fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), calcium (Ca), insulin, parathyroid hormone (PTH) and 25 hydroxyvitamin D3 (25 (OH) D3) were determined and the homeostasis model assessment-insulin resistance (HOMA-IR), homeostasis model assessment-beta secretion (HOMA-beta) and quantitative insulin sensitivity check index (QUICKI) indices were calculated. The statistical analysis of experimental data indicates that there was a significant increase (p<0.0001) in mean 25(OH) D3 levels after one month supplementation with the vitamin (from 31.1±1.9 to 68.1±6.1 nmol/L). A significant decrease in serum insulin level (16.5±3.7 vs. 9.0±1.1 μU/mL; p<0.0001) was also found, together with significant improvement in functions of HOMA-IR (p<0.0001), HOMA-beta (p = 0.0006) and QUICKI (p<0.0001) in both sexes without any significant differences between them. This study shows that giving vitamin D supplement for one month to diabetic patients with insufficient vitamin level increases 25(OH) D3 concentrations and resulted in improvements in many diabetic indices.

Keywords:

Fasting blood glucose, glycosylated hemoglobin, HOMA-IR, HOMA-beta, QUICKI, type 2 diabetes, vitamin D deficiency, vitamin D supplementation

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Hammouh, F. G., Tukan, S. K., & Takruri, H. R. (2015). Effect of Vitamin D Supplementation in a Sample of Type 2 Diabetes Patients from Karak Governorate in Jordan. Pakistan Journal of Nutrition, 14(2), 75–79. https://doi.org/10.3923/pjn.2015.75.79
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