Research Article Open Access

Effects of Telfairia Occidentalis Seeds on the Serum Lipid Profile and Atherogenic Indices of Male Albino Wistar Rats

Authors

CORRESPONDING AUTHOR
Anaelechi J. Onuegbu
Department of Community Medicine, Nnamdi Azikiwe Univerisity, Nnewi Campus, Anambra State, Nigeria
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Japhet M. Olisekodiaka
Department of Community Medicine, Nnamdi Azikiwe Univerisity, Nnewi Campus, Anambra State, Nigeria
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Tochukwu Ude
Chemical Pathology Unit, Department of Medical Laboratory Science, Faculty of Health Science and Technology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
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Ubuo K. Amah
Department of Community Medicine, Nnamdi Azikiwe Univerisity, Nnewi Campus, Anambra State, Nigeria
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John E. Okwara
Department of Community Medicine, Nnamdi Azikiwe Univerisity, Nnewi Campus, Anambra State, Nigeria
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Chigozie Ifeadike
Department of Community Medicine, Nnamdi Azikiwe Univerisity, Nnewi Campus, Anambra State, Nigeria
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Olubunmi G. Ayelagbe
Department of Chemical Pathology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Published on: August 15, 2015
DOI 10.3923/pjn.2015.557.562
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Abstract

The effects of T. occidentalis on serum lipid profile, non-HDL cholesterol and atherogenic indices were investigated in male wistar rats. The rats were fed for 28 days on diet formulated to contain 12.5, 37.5 and 75 g by weight of T. occidentalis seeds while the control group was fed on standard rat diet. Total cholesterol, Triglyceride, LDL, HDL and VLDL cholesterol were determined on blood samples collected on the 28th day using standard methods while atherogenic indices and non-HDL cholesterol were calculated using internationally accepted formula. The supplemented diet led to significant decrease in serum total, LDL, VLDL and Non-HDL cholesterol relative to control (p<0.05) while inducing a significant increase in HDL cholesterol though the effect appeared more pronounced at 37.5 g/weight. The diet supplementation also led to significant decrease in CRR, AC and AIP (p<0.05). These results suggest a possible dose dependent protective role of T. occidentalis seed against development of cardiovascular disease and in the management of dyslipidaemic conditions.

Keywords:

Cardiovascular disease, telfairia occidentalis, wistar rats

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Onuegbu, A. J., Olisekodiaka, J. M., Ude, T., Amah, U. K., Okwara, J. E., Ifeadike, C., & Ayelagbe, O. G. (2015). Effects of Telfairia Occidentalis Seeds on the Serum Lipid Profile and Atherogenic Indices of Male Albino Wistar Rats. Pakistan Journal of Nutrition, 14(9), 557–562. https://doi.org/10.3923/pjn.2015.557.562
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