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Effect of a Lipid-Based Nutrient Supplement on Insulin-like Growth Factor-1 Level (IGF-1) in 6-12 Month-old Children in South Central Timor of the East Nusa Tenggara Province
Abstract
Objective: This study aimed to assess the effect of a lipid-based nutrient supplement (LNS) on the levels of insulin-like growth factor-1 (IGF-1) in 6-12 month-old children in South Central Timor, East Nusa Tenggara province. Materials and Methods: This study used a quasi-experimental design that was carried out in 9 districts of South Central Timor. The samples were divided into the LNS group (n = 24), the MP-ASI SUN (Breast feeding supplementary food group) (n = 24) and the control group (n = 24). Examination of IGF-1 was conducted by the ELISA method, followed by 3 months LNS intervention. Results: The results showed that the factors associated with the level of IGF-1 were consumption of protein (p = 0.002), zinc (p = 0.013), phosphorus (p = 0.000), family income (p = 0.023) and length of the breast feeding period (p = 0.000). The median IGF-1 level before the intervention in the LNS group was -0.004 ng mL–1 and the median IGF-1 level after the intervention was 3.75. Before the intervention, the median IGF-1 in the MP-ASI group was 0.005 and the median IGF-1 level was 0.21 ng mL–1 after the intervention. In the control group, the median IGF-1 level before the intervention was -0.005 and the median IGF-1 level after the intervention was -1.48 ng mL–1. Conclusion: There were differences in the levels of IGF-1 after the intervention between the LNS and control groups (p = 0.000, p<0.05) and between the MP-ASI SUN group and the control group (p = 0.025, p<0.05) but there was no difference between the LNS and MP-ASI SUN groups (p = 0.066, p>0.05).
Keywords:
IGF-1, lipid-based nutrient supplement, MP-ASI SUN, phosphorus, protein, zincArticle Metrics
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Rantesalu, M. (2017). Effect of a Lipid-Based Nutrient Supplement on Insulin-like Growth Factor-1 Level (IGF-1) in 6-12 Month-old Children in South Central Timor of the East Nusa Tenggara Province. Pakistan Journal of Nutrition, 16(6), 417–425. https://doi.org/10.3923/pjn.2017.417.425
References
1.
WHO., 2011. Sixty-fourth world health assembly. Resolution WHA 64.28. World Health Organization, Geneva,
2.
UNICEF., 2012. End placing children under three years in institutions. United Nations Childrens Fund, Geneva.
3.
Wang, R.J., I. Trehan, L.N. LaGrone, A.J. Weisz, C.M. Thakwalakwa, K.M. Maleta and M.J. Manary, 2013. Investigation of food acceptability and feeding practices for lipid nutrient supplements and blended flours used to treat moderate malnutrition. J. Nutr. Edu. Behav., 45: 258-263.
4.
Adu-Afarwuah, S., A. Lartey, K.H. Brown, S. Zlotkin, A. Briend and K.G. Dewey, 2008. Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. Am. J. Clin. Nutr., 87: 929-938.
5.
Matilsky, D.K., K. Maleta, T. Castleman and M.J. Manary, 2009. Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children. J. Nutr., 139: 773-778.
6.
Riskesdas, 2010. Reports results health research, RISKESDAS 2010. Healthy Indonesia 2010, The Ministry of Health, Jakarta.
7.
The Profile of Indonesia Health, 2011. Indonesia demographic and health survey. Ministry of Health, Jakarta, Indonesia.
8.
Riskesdas, 2013. Basic health research Riskesdas 2013. Agency for Health Research and Development, Jakarta.
9.
WHO., 2009. Global Health Risks: Mortality and Burden of Disease Attributable to Selected Major Risks. World Health Organization, Geneva, Switzerland, ISBN: 13-9789241563871, Pages: 62.
10.
Health Office of South Central Timor, 2012. Health profile of South Central Timor district. Soe: Health Office of South Central Timor, Indonesian, pp: 25-29.
11.
TTS., 2011. Development of multimedia interactive learning games crosswords to. Learning information and communications technology, Universitas Pendidikan Indonesia.
12.
Delafontaine, P., Y.H. Song and Y. Li, 2004. Expression, regulation and function of IGF-1, IGF-1R and IGF-1 binding proteins in blood vessels. Arteriosclerosis, Thrombosis Vascular Biol., 24: 435-444.
13.
Sunarto, 2009. Therapeutic Contract Law in Indonesia, Reader. Nation Press, Medan.
14.
Owino, V., 2010. Why lipid-based ready to use foods (RUF) must be key components of strategies to manage acute malnutrition in resource poor settings. Afr. J. Food. Agric. Nutr. Dev., Vol. 10.
15.
Thakwalakwa, C., P. Ashorn, J. Phuka, Y.B. Cheung, A. Briend, T. Puumalainen and K. Maleta, 2010. A lipid-based nutrient supplement but not corn-soy blend modestly increases weight gain among 6-to 18-month-old moderately underweight children in rural Malawi. J. Nutr., 140: 2008-2013.
16.
Wang, A.Y.M., J. Sanderson, M.M.M. Sea, M. Wang and C.W.K. Lam et al., 2003. Important factors other than dialysis adequacy associated with inadequate dietary protein and energy intakes in patients receiving maintenance peritoneal dialysis. Am. J. Clin. Nutr., 77: 834-841.
17.
Motarjemi, Y., 2013. Encyclopedia of Food Safety. Academic Press, New York.
18.
Cercamondi, C.I., I.M. Egli, E. Mitchikpe, F. Tossou and J. Hessou et al., 2013. Iron bioavailability from a lipid-based complementary food fortificant mixed with millet porridge can be optimized by adding phytase and ascorbic acid but not by using a mixture of ferrous sulfate and sodium iron EDTA. J. Nutr., 143: 1233-1239.
19.
Wang, Y.Y., F.Z. Wang, K.A. Wang, C.M. Chen and M. Jin, 2006. Effects of nutrient fortified complementary food supplements on development of infants and young children in poor rural area of Gansu province. Wei Sheng Yan Jiu [J. Hygiene Res.], 35: 772-774.
20.
Phuka, J.C., M. Gladstone, K. Maleta, C. Thakwalakwa and Y.B. Cheung et al., 2012. Developmental outcomes among 18-month-old Malawians after a year of complementary feeding with lipid-based nutrient supplements or corn-soy flour. Maternal Child Nutr., 8: 239-248.
21.
Saleh, A., 2008. Penerapan maternal role attaintment untuk tumbuh kembang bayi. April 9, 2008. https://www.mysciencework.com/publication/show/5f515ea9c4f13d8b28006311538ac670.
22.
Smith, W.J., L.E. Underwood, L. Keyes and D.R Clemmons, 1997. Use of Insulin-like growth factor I (IGF-I) and IGF-binding protein measurements to monitor feeding of premature infants 1. J. Clin. Endocrinol. Metab., 82: 3982-3988.
23.
Maes, M., Y. Amand, L.E. Underwood, D. Maiter and J.M. Ketelslegers, 1988. Decreased serum insulin-like growth factor I response to growth hormone in hypophysectomized rats fed a low protein diet: Evidence for a postreceptor defect. Acta Endocrinol., 117: 320-326.
24.
Leray, V., B. Siliart, H. Dumon, L. Martin, R. Sergheraert, V. Biourge and P. Nguyen, 2006. Protein intake does not affect insulin sensitivity in normal weight cats. J. Nutr., 136: 2028S-2030S.
25.
Underwood, A.J., 1994. On beyond BACI: Sampling designs that might reliably detect environmental disturbances. Ecol. Applic., 4: 3-15.
26.
Yakar, S., C.J. Rosen, M.L. Bouxsein, H. Sun and W. Mejia et al., 2009. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J., 23: 709-719.
27.
Maggio, A., G. Barbieri, G. Raimondi and S. De Pascale, 2010. Contrasting effects of GA3 treatments on tomato plants exposed to increasing salinity. J. Plant Growth Regul., 29: 63-72.
28.
MacDonald, R.S., L.C. Wollard-Biddle, J.D. Browning, W.H. Thornton and B.L. O'Dell, 1998. Zinc deprivation of murine 3T3 cells by use of diethylenetrinitrilopentaacetate impairs DNA synthesis upon stimulation with insulin-like growth factor-I (IGF-I). J. Nutr., 128: 1600-1605.
29.
Norat, T., A. Lukanova, P. Ferrari and E. Riboli, 2002. Meat consumption and colorectal cancer risk: Doseâ€response metaâ€analysis of epidemiological studies. Int. J. Can., 98: 241-256.
30.
Hurks, R., I.E. Hoefer, A. Vink, G. Pasterkamp and A. Schoneveld et al., 2010. Different effects of commonly prescribed statins on abdominal aortic aneurysm wall biology. Eur. J. Vascular Endovascular Surg., 39: 569-576.
31.
Gerschman, R. and A.D. Marenzi, 1935. Normal Values for the Blood Calcium. Vol. 8, C. R. Society Biology, Paris, pp: 120, 817.
32.
Rivera, J.A., C. Hotz, T. Gonzalez-Cossio, L. Neufeld and A. Garcia-Guerra, 2003. The effect of micronutrient deficiencies on child growth: A review of results from community-based supplementation trials. J. Nutr., 133: 4010S-4020S.
33.
Mane, N.B., K.B. Simondon, A. Diallo, A.M. Marra and F. Simondon, 2006. Early breastfeeding cessation in rural Senegal: Causes, modes and consequences. Am. J. Public Health, 96: 139-144.
34.
Hasmi and A. Mallongi, 2016. Health risk analysis of lead exposure from fish consumption among communities along Youtefa Gulf, Jayapura. Pak. J. Nutr., 15: 929-935.
35.
Nur, R. and A. Mallongi, 2016. Impact of violence on health reproduction among wives in donggala. Pak. J. Nutr., 15: 980-988.
36.
Mallongi, A., A. Daud, H. Ishak, R.L. Ane and A.B. Birawida et al., 2017. Clean water treatment technology with an up-flow slow sand filtration system from a well water source in the Tallo District of Makassar. J. Environ. Sci. Technol., 10: 44-48.
37.
Moyerâ€Mileur, L.J., H. Slater, K.C. Jordan and M.A. Murray, 2008. IGFâ€1 and IGFâ€binding proteins and bone mass, geometry and strength: Relation to metabolic control in adolescent girls with type 1 diabetes. J. Bone Mineral Res., 23: 1884-1891.
38.
Katz, M., I. Sarvary, T. Frejd, B. Hahn-Hagerdal and M.F. Gorwa-Grauslund, 2002. An improved stereoselective reduction of a bicyclic diketone by Saccharomyces cerevisiae combining process optimization and strain engineering. Applied Microbiol. Biotechnol., 59: 641-648.
39.
Ong, K.K., M. Langkamp, M.B. Ranke, K. Whitehead, I.A. Hughes, C.L. Acerini and D.B. Dunger, 2009. Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: The Cambridge baby growth study. Am. J. Clin. Nutr., 90: 156-161.
40.
Yani, R.W.E., A. Mallongi, S. Andarini, D. Prijatmoko and I.R. Dewanti, 2016. The effect of zinc saliva on the toddlers nutritional status. J. Int. Dental Med. Res., 9: 29-32.
41.
Rantesalu, M., 2015. The effect of the lipid-based nutrient supplement (Lns) on the level of the insulin-likegrowth factor-1 (Igf-1) in 6-12 old children in South central timor East Nusa Tenggara propince. Ph.D. Thesis, Hasanuddin University, Makassar, Indonesia.
