Relationship between a Pro-thrombotic State and Anthropometric Parameters in Young Saudi Females: A Preliminary Study
DOI:
https://doi.org/10.3923/pjn.2018.146.151Keywords:
Body mass index, obesity, partial thromboplastin time, prothrombin time, waist/hip ratioAbstract
Background and Objective: A global epidemic increase in obesity prevalence has been observed in most of the countries. This phenomenon is an emerging health problem that is associated with increasing prevalence of obesity-related co-morbidities. This study sought to investigate whether a pro-thrombotic state is related to anthropometric parameters in a student population. Materials and Methods: Forty young adult females aged 20-30 years (mean age: 21.0±3.04 years) were included in the study. Participants were sub-divided into three groups: The lean (n = 12) group, which included individuals with a body mass index (BMI) between 18 and 24.9 kg m–2, the overweight/obese (n = 16) group, which included individuals with a BMI >25 kg m–2 and the obese diabetic group (n = 16), which included individuals with a BMI >30 kg m–2 and diabetes mellitus (DM). Anthropometric measurements, including BMI, waist circumference (WC), hip circumference (HC) and the waist/hip (W/H) ratio were determined and calculated in this study and hemostatic metrics were assessed. Results: The mean prothrombin times (PTs) were 11.9±0.9, 11.2±0.4 and 11.7±0.9 sec in the lean, overweight/obese and obese diabetic groups, respectively. The examined groups exhibited a negative correlation between PT and BMI (r = -0.4, p = 0.06) and a positive correlation between PT and W/H ratio (r = 0.5, p = 0.04). No other significant correlations between BMI or W/H ratio and other hematological indices were observed. Conclusion: Obesity could be associated with hemostatic changes that favor the development of thrombosis, this possibility highlights the need for the implementation of preventative measures.
References
Nejat, E.J., A.J. Polotsky and L. Pal, 2010. Predictors of chronic disease at midlife and beyond-the health risks of obesity. Maturitas, 65: 106-111.
Allman-Farinelli, M.A., T. Chey, A.E. Bauman, T. Gill and W.P. James, 2008. Age, period and birth cohort effects on prevalence of overweight and obesity in Australian adults from 1990 to 2000. Eur. J. Clin. Nutr., 62: 898-907.
El-Hazmi, M.A. and A.S. Warsy, 2000. Prevalence of overweight and obesity in diabetic and non-diabetic Saudis. East Mediterr. Health J., 6: 276-282.
Fawzy, M.S., O. Alhadramy, M.H. Hussein, H.M. Ismail, N.M. Ismail, N.M. Biomy and E.A. Toraih, 2015. Functional and structural impact of ATP-binding cassette transporter A1 R219K and I883M gene polymorphisms in obese children and adolescents. Mol. Diagn. Ther., 19: 221-234.
Aitken, R.J., M.A. Allman-Farinelli, L.A. King and A.E. Bauman, 2009. Current and future costs of cancer, heart disease and stroke attributable to obesity in Australia-a comparison of two birth cohorts. Asia Pac. J. Clin. Nutr., 18: 63-70.
Lee, M.J., Y. Wu and S.K. Fried, 2013. Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications. Mol. Aspects Med., 34: 1-11.
Juhan-Vague, I. and M.C. Alessi, 2008. Abdominal obesity, insulin resistance and alterations in hemostasis. Official J. Int. Chair Cardiometabolic Risk, 1: 11-16.
Albow, B.M. and A.K. Alenezy, 2016. Risk factors of type 2 diabetes and cardiovascular diseases among Saudi Arabian adolescents. Pak. J. Nutr., 15: 883-888.
Li, C., E.S. Ford, A.H. Mokdad and S. Cook, 2006. Recent trends in waist circumference and waist-height ratio among US children and adolescents. Pediatrics, 118: e1390-e1398.
Abolfotouh, M.A., S.A. Sallam, M.S. Mohammed, A. Loutfy and A.A. Hasab, 2011. Prevalence of elevated blood pressure and association with obesity in Egyptian school adolescents. Int. J. Hypertens.
Dacie, J.V. and S.M. Lewis, 1972. Paroxysmal nocturnal haemoglobinuria: Clinical manifestations, haematology and nature of the disease. Ser. Haematol., 5: 3-23.
Poller, L., S. Ibrahim, J. Jespersen and A. Pattison, 2012. Coagulometer international sensitivity index (ISI) derivation, a rapid method using the prothrombin time/international normalized ratio (PT/INR) line: A multicenter study. J. Thromb. Haemost., 10: 1379-1384.
Camp, H.S., D. Ren and T. Leff, 2002. Adipogenesis and fat-cell function in obesity and diabetes. Trends Mol. Med., 8: 442-447.
Al-Nozha, M.M., Y.Y. Al-Mazrou, M.A. Al-Maatouq, M.R. Arafah and M.Z. Khalil et al., 2005. Obesity in Saudi Arabia. Saudi Med. J., 26: 824-829.
Bahathiq, S. and A. Omar, 2010. Relationship of leptin hormones with body mass index and waist circumference in Saudi female population of the Makkah community. Open Obesity J., 2: 95-100.
Stoppa-Vaucher, S., M.A. Dirlewanger, C.A. Meier, P. de Moerloose and G. Reber et al., 2012. Inflammatory and prothrombotic states in obese children of European descent. Obesity, 20: 1662-1668.
Kornblith, L., B. Howard, R. Kunitake, B. Redick, M. Nelson, M.J. Cohen and R. Callcut, 2015. Obesity and clotting: BMI independently contributes to hypercoagulability after injury. J. Trauma Acute Care Surg., 78: 30-38.
Faber, D.R., P.G. de Groot and F.L.J. Visseren, 2009. Role of adipose tissue in haemostasis, coagulation and fibrinolysis. Obes. Rev., 10: 554-563.
Samad, F., M. Pandey and D.J. Loskutoff, 1998. Tissue factor gene expression in the adipose tissues of obese mice. Proc. Natl. Acad. Sci. USA., 95: 7591-7596.
Samad, F. and W. Ruf, 2013. Inflammation, obesity and thrombosis. Blood, 122: 3415-3422.
Riba, R., C.E. Hughes, A. Graham, S.P. Watson and K.M. Naseem, 2008. Globular adiponectin induces platelet activation through the collagen receptor GPVI-Fc receptor γ-chain complex. J. Thromb. Haemost., 6: 1012-1020.
Simpson, A.J., N.A. Booth, N.R. Moore and B. Bennett, 1991. Distribution of plasminogen activator inhibitor (PAI-1) in tissues. J. Clin. Pathol., 44: 139-143.
Montilla, M., M.J. Santi, M.A. Carrozas and F.A. Ruiz, 2014. Biomarkers of the prothrombotic state in abdominal obesity. Nutr. Hosp., 31: 1059-1066.
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