Effect of Sargassum hystrix Powder on the Biochemical Profile of Diabetic Wistar Rats
Authors
- Abdu Rohman Nurfahmi Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada, Jalan Flora Gedung A4 Bulaksumur, 55281 Yogyakarta, Indonesia
-
Amir Husni
Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada, Jalan Flora Gedung A4 Bulaksumur, 55281 Yogyakarta, Indonesia
- Alim Isnansetyo Department of Fisheries, Faculty of Agriculture, Universitas Gadjah Mada, Jalan Flora Gedung A4 Bulaksumur, 55281 Yogyakarta, Indonesia
DOI:
https://doi.org/10.3923/pjn.2018.248.254Keywords:
Blood glucose, diabetes, lipid profile, necrosis, Sargassum spAbstract
Objective: This study aimed to determine the effect Sargassum hystrix (S. hystrix) powder on the levels of glucose, lipid profile and pancreatic profile of diabetic wistar rats. Methodology: S. hystrix powder (SHP) was made by grinding and sieving to obtain a 120 mesh sized powder. The diabetic rats were administered 450, 600 and 750 mg kg–1 doses of SHP orally every day for 15 days. Glucose, lipid profile and weight of rats were measured when in the normal state (baseline) and on days 0 (diabetes), 5, 10 and 15. The histology of the pancreas was observed on the 15th day. Results: The 750 mg kg–1 dose of SHP was significantly able to reduce the level of preprandial glucose and postprandial glucose and did not have significant differences compared to the positive control. SHP did not affect the level of total cholesterol, triglycerides, HDLc and LDLc. Necrosis was found in all of the streptozotocin-induced rats. Conclusion: The SHP has the potential effect that can be beneficial for streptozotocin-induced diabetic rats.
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