Effect of Cinnamon Administration on Fertility of Normal and Diabetic Male Rats
Authors
- Mahmoud Al-Shawabkeh Faculty of Pharmacy, Applied Sciences Private University, Amman 19328, Jordan
-
Abdulrahim Al Jamal
Biological Sciences, Faculty of Sciences, Al al-Bayt University, Al-Mafraq, Jordan
DOI:
https://doi.org/10.3923/pjn.2019.491.495Keywords:
Cinnamon, epididymis, male infertility, normal and diabetic male rats, sperm count, sperm morphology, testosteroneAbstract
Background and Objective: Male infertility is one of the most common problem in the word. Diabetes is one of the chronic metabolic syndrome that was found to have direct effect on testicular malfunction. This study aimed to evaluate the enhancement effect of cinnamon bark powder on fertility parameters in normal and diabetic male wistar rats. Materials and Methods: A total of 40 male wistar rats were divided into two sets: normal and diabetic rats. Normal rats received either distilled water or 80 mg kg–1 day–1 of cinnamon only and diabetic rats received either distilled water or 80 mg kg–1 day–1 of cinnamon only. Cinnamon powder was suspended in distilled water. After four weeks all groups were euthanized and analyzed for testosterone, epididymis weight, sperm count, motility and morphology with proper technique. Results: The result showed that cinnamon as powder exerted significant changes on fertility parameters in both normal and diabetic rats including testosterone, epididymis, total sperm count, motility and sperm morphology (normal sperm count, abnormal head sperms, abnormal tail sperms). Also it was noticed that diabetic rats gain higher beneficial improvement changes in fertility parameters than normal rats. Conclusion: Ingestion of cinnamon bark found to improve significantly infertility parameters in both normal and diabetic male rats which may give promising solution to the problem, however more effective on diabetic than normal rats.
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