Relationship Between Serum Zinc Concentration with Post-partum Depression among Women in Coastal Area of Indonesia


Authors

  • R. Indriasari Department of Nutrition, Faculty of Public Health, Hasanuddin University, Jln. Perintis Kemerdekaan KM. 10, Tamalanrea, Makassar 90245, Indonesia
  • Y. Kurniati Departmentof Public Health, Faculty of Medicine and Health Science, Alauddin State Islamic University, Makassar 90245, South Sulawesi, Indonesia
  • A. Syam Department of Nutrition, Faculty of Public Health, Hasanuddin University, Jln. Perintis Kemerdekaan KM. 10, Tamalanrea, Makassar 90245, Indonesia
  • S. Syamsuddin Faculty of Medicine Science, Hasanuddin University, Makassar 90245, South Sulawesi, Indonesia
  • M.A Mansur Department of Nutrition, Faculty of Public Health, Hasanuddin University, Jln. Perintis Kemerdekaan KM. 10, Tamalanrea, Makassar 90245, Indonesia
  • S. Amir Department of Nutrition, Faculty of Public Health, Hasanuddin University, Jln. Perintis Kemerdekaan KM. 10, Tamalanrea, Makassar 90245, Indonesia

DOI:

https://doi.org/10.3923/pjn.2019.747.752

Keywords:

Coastal area, depression, Indonesia, micronutrient, postpartum, women's health, zinc deficiency

Abstract

Background and Objective: Women in coastal area have limited access to nutritious diet and vulnerable to micronutrient deficiencies, including zinc. Zinc deficiency is believed to play an important role in the development of mood disorders such as post-partum depression. Therefore, we aimed to determine the relationship between serum zinc concentration and post-partum depression among women in coastal area of Indonesia. Materials and Methods: Edinburgh Postnatal Depression Score (EDPS) was administered to 87 post-partum women to determine the post-partum depression symptoms. Serum zinc was measured with ELISA method using Bio Assay Quanti Chrome Zinc Assay Kit (DIZN-250). Data was analyzed using chi-square and Pearson correlation test. Results: Results showed that 35.5% of mothers experienced post-partum depression symptoms and 57.4% of mothers had very low serum zinc. There was no significant relationship between serum zinc level and postpartum depression (p = 0.729). Moreover, Pearson correlation test shows a weak correlation between serum zinc concentration and EPDS score ® = -0.063, p = 0.564). Although not significant and weak, this inverse correlation indicated that as the serum zinc concentration increased the EPDS score decreased. Conclusion: There was no significant relationship between serum zinc level and postpartum depression, however, high percentage of women with post-partum depression symptoms and zinc deficiency implies that more attentions should be placed to post-partum women’s mental health and zinc status.

References

Skalkidou, A., S.M. Sylven, F.C. Papadopoulos, M. Olovsson, A. Larsson and I. Sundstrom-Poromaa, 2009. Risk of postpartum depression in association with serum leptin and interleukin-6 levels at delivery: A nested case-control study within the UPPSAT cohort. Psychoneuroendocrinology, 34: 1329-1337.

Motzfeldt, I., S. Andreasen, A.L. Pedersen and M.L. Pedersen, 2013. Prevalence of postpartum depression in Nuuk, Greenland-a cross-sectional study using Edinburgh Postnatal Depression Scale. Int. J. Circumpolar Health, Vol. 72.

Dennis, C.L., M. Heaman and S. Vigod, 2012. Epidemiology of postpartum depressive symptoms among Canadian women: Regional and national results from a cross-sectional survey. Can. J. Psychiatry, 57: 537-546.

Dietz, P.M., S.B. Williams, W.M. Callaghan, D.J. Bachman, E.P. Whitlock and M.C. Hornbrook, 2007. Clinically identified maternal depression before, during and after pregnancies ending in live births. Am. J. Psychiatry, 164: 1515-1520.

Chandran, M., P. Tharyan, J. Muliyil and S. Abraham, 2002. Post-partum depression in a cohort of women from a rural area of Tamil Nadu, India: Incidence and risk factors. Br. J. Psychiatry, 181: 499-504.

Ibrahim, F., Rahma and M. Ikhsan, 2012. [Factors related to postpartum depression in the Rsia Pertiwi Makassar in 2012]. Repository UNHAS. http://repository.unhas.ac.id/bitstream/handle/123456789/4250/Fatma%20Ibrahim%20(K11108297).pdf?sequence=1, (In Indonesian).

Dira, I.K.P.A. and A.A.S. Wahyuni, 2016. [Prevalence and risk factor of post-partum depression in Denpasar using Edinburgh Postnatal Depression Scale]. E-Jurnal Medika, 5: 1-5, (In Indonesian).

Syah, M.N.H., A.R. Thaha and Citrakesumasari, 2012. [The status of micro nutrient content (iron, folic acid and zinc) and DNA damage of anemia in pregnant women in Bontonompo and South Bontonompo districts of Gowa Regency in 2012]. Program Studi Ilmu Gizi Fakultas Kesehatan Masyarakat Universitas Hasanuddin. http://pasca.unhas.ac.id/jurnal/files/7ea95f22be12960b243855c387d29dc0.pdf, (In Indonesian).

Kurniati, Y., 2017. [The role of zinc and psychosocial factor on postpartum blues]. Graduate Theses, Hasanuddin University, Makassar, Indonesia, (In Indonesian).

Donaldson, J., T. St. Pierre, J.L. Minnich and A. Barbeau, 1973. Determination of Na+, K+, Mg2+, Cu2+, Zn2+ and Mn2+ in rat brain regions. Can. J. Biochem., 51: 87-92.

Mlyniec, K., E. Trojan, J. Slusarczyk, K. Glombik and A. Basta-Kaim et al., 2016. Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder. J. Neuroimmunol., 291: 11-17.

Sawada, T. and K. Yokoi, 2010. Effect of zinc supplementation on mood states in young women: A pilot study. Eur. J. Clin. Nutr., 64: 331-333.

Marcellini, F., C. Giuli, R. Papa, M. Malavolta and E. Mocchegiani, 2006. Psychosocial aspects and zinc status: Is there a relationship with successful aging? Rejuvenation Res., 9: 333-337.

DiGirolamo, A.M. and M. Ramirez-Zea, 2009. Role of zinc in maternal and child mental health. Am. J. Clin. Nutr., 92: 940S-945S.

Ellsworth-Bowers, E.R. and E.J. Corwin, 2012. Nutrition and the psychoneuroimmunology of postpartum depression. Nutr. Res. Rev., 25: 180-192.

Wojcik, J., D. Dudek, M. Schlegel-Zawadzka, M. Grabowska and A. Marcinek et al., 2006. Antepartum/postpartum depressive symptoms and serum zinc and magnesium levels. Pharmacol. Rep., 58: 571-576.

Walker, S.P., T.D. Wachs, J.M. Gardner, B. Lozoff and G.A. Wasserman et al., 2007. Child development: Risk factors for adverse outcomes in developing countries. Lancet, 369: 145-157.

Siwek, M., B. Szewczyk, D. Dudek, K. Styczen and M. Sowa-Kucma et al., 2013. Zinc as a marker of affective disorders. Pharmacol. Rep., 65: 1512-1518.

Swardfager, W., N. Herrmann, G. Mazereeuw, K. Goldberger, T. Harimoto and K.L. Lanctot, 2013. Zinc in depression: A meta-analysis. Biol. Psychiatry, 74: 872-878.

Maserejian, N.N., S.A. Hall and J.B. McKinlay, 2012. Low dietary or supplemental zinc is associated with depression symptoms among women, but not men, in a population-based epidemiological survey. J. Affective Disord., 136: 781-788.

Edalati-Fard, F., M. Mirghafourvand, S. Mohammad-Alizadeh-Charandabi and A. Farshbaf-Khalili, 2015. Relationship of zinc and magnesium serum levels with postpartum depression in Tabriz-Iran. Global J. Health Sci., 8: 120-126.

Downloads

Published

15.07.2019

Issue

Section

Research Article

How to Cite

Indriasari, R., Kurniati, Y., Syam, A., Syamsuddin, S., Mansur, M., & Amir, S. (2019). Relationship Between Serum Zinc Concentration with Post-partum Depression among Women in Coastal Area of Indonesia. Pakistan Journal of Nutrition, 18(8), 747–752. https://doi.org/10.3923/pjn.2019.747.752