Is Ratio of Omega-3/Omega-6 Fatty Acids Intake Related with the Level of Omega-3 in the Membrane of Erythrocyte among Institutionalized Elderly?
Authors
-
Nita
Department of Nutrition, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia
- Sri Widia A. Jusman Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
- Diyah Eka Andayani Department of Nutrition, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia
DOI:
https://doi.org/10.3923/pjn.2020.388.392Keywords:
Elderly population, health problems, inflammaging, institutionalized elderly, level of omega-3 erythrocyte membrane, ratio of omega-3/omega-6 intakeAbstract
Background and Objective: Increased life expectancy also causes an increase in various diseases associated with inflammation. Omega-3 fatty acids are known to have anti-inflammatory effects but these effects are influenced by the presence of omega-6 fatty acids because they compete in the synthesis of eicosanoids. Therefore, the ratio of omega-3 and omega-6 fatty acid intake is important to consider. The ratio of omega-3 and omega-6 fatty acid intake will affect the level of omega-3 fatty acids in the blood. This study aimed to explore the relationship between the ratio of omega-3 / omega-6 fatty acid intake with the level of omega-3 fatty acid of erythrocyte membranes in the elderly in five registered nursing homes in South Tangerang City. Materials and Methods: This cross-sectional study involved 101 elderly subjects using proportional random sampling method. The ratio of omega-3 and omega-6 fatty acid intake was assessed using a semi-quantitative food frequency questionnaire (SQ-FFQ) and the omega-3 fatty acid levels of the erythrocyte membrane were measured using gas chromatography-mass spectrometry. We use Spearman's analysis to see the correlation. Results: The mean age of the participants was 75.5±7.6 years and the majority of participants were women (73.3%). Furthermore, the median ratio of omega-3 and omega-6 fatty acid intake was 0.08 (0.05-0.23) and the median value of erythrocyte membrane omega-3 fatty acids for ALA = 10.06 (4.9-24.9) μg mL–1, EPA = 14.6 (5.06 - 81.02) ug mL–1, DHA = 115.5 (20.6-275.09) ug mL–1, total omega-3 = 144.1 (89.3 - 332.1) μg mL–1. Conclusion: No correlation was found between the ratio of omega-3/omega-6 fatty acid intake with the level of omega-3 fatty acid erythrocyte membrane among institutionalized elderly. (r = -0.06, p = 0.6 for ALA; r = 0.06, p = 0.5 for EPA, r = -0.07, p = 0.5 for DHA and r = -0.06, p = 0.5 for total omega-3).
References
United Nations, Department of Economic and Social Affairs, Population Division 2015. World Population Ageing 2015. United Nations New York, Pages: 149.
Setiati, S., 2013. Geriatric medicine, sarkopenia, frailty, dan kualitas hidup pasien usia lanjut: tantangan masa depan pendidikan, penelitian dan pelayanan kedokteran di Indonesia. eJournal Kedokteran Indonesia, 1: 234-242.
Ferrucci, L. and E. Fabbri, 2018. Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat. Rev. Cardiol., 15: 505-522.
Calder, P.C., N. Bosco, R. Bourdet-Sicard, L. Capuron and N. Delzenne et al., 2017. Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition. Ageing Res. Rev., 40: 95-119.
Innes, J.K. and P.C. Calder, 2018. Omega-6 fatty acids and inflammation. Prostaglandins, Leukotrienes Essent. Fatty Acids 132: 41-48.
Olliver, M., M. Veysey, M. Lucock, S. Niblett, K. King, L. MacDonald-Wicks and M.L. Garg, 2016. Erythrocyte omega-3 polyunsaturated fatty acid levels are associated with biomarkers of inflammation in older Australians. J. Nutr. Intermediary Metab., 5: 61-69.
Ongan, D. and N. Rakıcıoğlu, 2015. Nutritional status and dietary intake of institutionalized elderly in Turkey: A cross-sectional, multi-center, country representative study. Arch. Gerontology Geriatrics, 61: 271-276.
World Health Organization. Regional Office for the Western Pacific, 2000. The Asia-Pacific perspective : redefining obesity and its treatment. Health Communications Australia. Sydney, Australia Pages: 55.
Mahoney, F.I. and D.W. Barthel, 1965. Functional evaluation: The barthel index. Md. State Med. J., 14: 61-65.
Curcio, F., I. Liguori, M. Cellulare, G. Sasso and D. Della-Morte et al., 2019. Physical activity scale for the elderly (pase) score is related to sarcopenia in noninstitutionalized older adults. J. Geriatric Phys. Ther., 42: 130-135.
Logan, S., B. Gottlieb, S. Maitland, D. Meegan and L. Spriet, 2013. The physical activity scale for the elderly (PASE) questionnaire; does it predict physical health? Int. J. Environ. Res. Public Health, 10: 3967-3986.
Washburn, R.A., K.W. Smith, A.M. Jette and C.A. Janney, 1993. The physical activity scale for the elderly (PASE): Development and evaluation. J. Clin. Epidemiol., 46: 153-162.
Gellert, S., J.P. Schuchardt and A. Hahn, 2017. Low long chain omega-3 fatty acid status in middle-aged women. Prostaglandins, Leukotrienes and Essential Fatty Acids 117: 54-59.
Jones, P.J.H. and T. Rideout, 2014. Lipids, Sterols, and Their Metabolites. In: Modern Nutrition in Health and Disease, Ross, A.C., (Ed.). Lippincott Williams & Wilkins, Philadelphia, Pennsylvania pp: 77-79.
Harris, W.S., J.V. Pottala, S.M. Lacey, R.S. Vasan, M.G. Larson and S.J. Robins, 2012. Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the framingham heart study. Atherosclerosis, 225: 425-431.
Harris, W.S., J.V. Pottala, S.A. Varvel, J.J. Borowski, J.N. Ward and J.P. McConnell, 2013. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: Observations from 160,000 patients. Prostaglandins, Leukotrienes Essent. Fatty Acids, 88: 257-263.
Plourde, M., R. Chouinard-Watkins, M. Vandal, Y. Zhang, P. Lawrence, J.T. Brenna and S.C. Cunnane, 2011. Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderly. Nutr. Metab. (Lond), Vol. 8, No. 5.
Wagner, A., C. Simon, B. Morio, J. Dallongeville and J.B. Ruidavets et al., 2015. Omega-3 index levels and associated factors in a middle-aged French population: the MONA LISA-NUT study. Eur. J. Clin. Nutr., 69: 436-441.
Nordgren, T., E. Lyden, A. Anderson-Berry and C. Hanson, 2017. Omega-3 fatty acid intake of pregnant women and women of childbearing age in the United States: Potential for deficiency? Nutrients, Vol. 9, No. 197.
Block, R.C., W.S. Harris and J.V. Pottala, 2008. Clinical investigation: determinants of blood cell omega-3 fatty acid content. Open Biomarkers Journal, 1: 1-6.
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