The Extent of Acute Changes in Blood Glucose Levels (BGL) Followed by Consumption of Different Soft Drinks in Healthy Adult Females
DOI:
https://doi.org/10.3923/pjn.2020.438.443Keywords:
Artificial sweeteners, blood glucose, caffeine, insulin sensitivity, soft drinksAbstract
Background and Objective: Now-a-days soft drinks are more favourite refreshment among people all over the world. These non-alcoholic drinks are usually carbonated, sweetened with sugars or artificial sweeteners, edible acids, natural or artificial flavours and colours. Present study was designed to measure and compare the immediate changes in blood glucose levels (BGL) after consuming different soft drinks based on their ingredients, in healthy adult females. Materials and Methods: For this purpose, after recording the postprandial blood glucose concentrations, all participants were randomly divided into 4 groups, were asked to consume 4 different brands of selected soft drinks. At 30, 60, 90 and 120 min of intervals BGL were measured. Results: After 30 min the groups who consumed brand I, III and IV showed a rise in the mean BGL due to the presence of simple sugars, whereas, consumption of brand II containing artificial sweetener did not show such trend, instead mean BGL decreased from baseline values. After 60 min, the groups who consumed brands I, II and IV showed a significant decline in mean BGL and indicated the release of insulin, while a slow reduction in mean BGL was observed in group consuming brand III which showed caffeine-induced decreased insulin sensitivity. In between 60-90 min the mean BGL again raised to maintain blood glucose concentration followed by glucagon release with brands I, II and IV. After 120 min, the mean BGL was lower in groups who consumed brands I, II and III than that of the initial (postprandial) blood glucose concentrations. Conclusion: As all brands of selected soft drinks not only contained different categories of sweeteners but some additives with their health-related harmful effects, so the best approach for patients of diabetes and metabolic disorders is to avoid or limit the intake of soft drinks. However, for normal healthy persons, it is better to consume a drink with minimum artificial additives.
References
Dobrinas, S., A. Soceanu, G. Stanciu and V. Popescu, 2013. Quantification of sugar in different brands of drinks. Ovidius Univ. Ann. Chem., 24: 138-140.
Gatenby, S.J., 2003. Dietary Importance. In: Encyclopedia of Food Sciences and Nutrition. Caballero, B. (Ed.). Academic Press, United States pp: 5366-5370.
Shenkin, J.D., K.E. Heller, J.J. Warren and T.A. Marshall, 2003. Soft drink consumption and caries risk in children and adolescents. Gen Dent., 51: 30-36.
Yang, L., P. Bovet, Y. Liu, M. Zhao, C. Ma, Y. Liang and B. Xi, 2017. Consumption of carbonated soft drinks among young adolescents aged 12 to 15 years in 53 low- and middle-income countries. Am. J. Public Health, 107: 1095-1100.
Benajiba, N. and S.M. Mahboub, 2019. Consumption of sugar-sweetened soft drinks among Saudi adults: assessing patterns and identifying influencing factors using principal component analysis. Pak. J. Nutr., 18: 401-407.
Datta, B.K. and M.J. Husain, 2020. Carbonating the household diet: a Pakistani tale. Public Health Nutr., 23: 1629-1637.
Muhammad, L.H.F. and K.M. Dickinson, 2017. Nutrients, Energy Values and Health Impact of Conventional Beverages. In: Nutrients in Beverages. Grumezescu, A.M. and A.M. Holban (Eds.). Academic Press. United States pp: 41-75.
Ashurst, P.R., 2016. Chemistry and Technology of Soft Drinks and Fruit Juices. 3rd Edn., John Wiley & Sons, Ltd. United States Pages: 421.
Hu, F.B. and V.S. Malik, 2010. Sugar-sweetened beverages and risk of obesity and type 2 diabetes: Epidemiologic evidence. Physiol. Behav., 100: 47-54.
Kregiel, D., 2015. Health safety of soft drinks: contents, containers, and microorganisms. BioMed. Res. Int., Vol. 2015.
Marcus, J.B., 2013. Fluid Basics: Healthfully Meeting Fluid Needs: Healthy Fluid Choices, Roles and Applications. In: Culinary Nutrition. Marcus, J.B. (Ed.). Academic Press, United States pp: 333-370.
Dhingra, R., L. Sullivan, P.F. Jacques, T.J. Wang and C.S. Fox et al., 2007. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation, 116: 480-488.
Reilly, J.J. and J. Kelly, 2011. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. Int. J. Obesity, 35: 891-898.
Manyema, M., J.L. Veerman, L. Chola, A. Tugendhaft, D. Labadarios and K. Hofman, 2015. Decreasing the burden of type 2 diabetes in south africa: the impact of taxing sugar-sweetened beverages. PLoS ONE.
Singh, G.M., R. Micha, S. Khatibzadeh, S. Lim, M. Ezzati and D. Mozaffarian, 2015. Estimated global, regional and national disease burdens related to sugar-sweetened beverage consumption in 2010. Circulation, 132: 639-666.
Aamir, A.H., Z. Ul-Haq, S.A. Mahar, F.M. Qureshi and I. Ahmad et al., 2019. Diabetes Prevalence Survey of Pakistan (DPS-PAK): prevalence of type 2 diabetes mellitus and prediabetes using HbA1c: a population-based survey from Pakistan. BMJ Open, Vol. 9, No. 2.
Keller, A. and S.B.D. Torre, 2015. Sugar-sweetened beverages and obesity among children and adolescents: a review of systematic literature reviews. Childhood Obesity, 11: 338-346.
Wilder, J.R., L.M. Kaste, A. Handler, T. Chappleâ€McGruder and K.M. Rankin, 2016. The association between sugarâ€sweetened beverages and dental caries among thirdâ€grade students in Georgia. J. Public Health Dent., 76: 76-84.
Carwile, J.L., W.C. Willett, D. Spiegelman, E. Hertzmark, J. Rich-Edwards, A.L. Frazier, K.B. Michels, 2015. Sugar-sweetened beverage consumption and age at menarche in a prospective study of US girls. Hum. Reprod., 30: 675-683.
Ziegler, A.M. and J.L. Temple, 2015. Soda consumption is associated with risk-taking behaviors in adolescents. Am. J. Health Behav., 39: 761-771.
Mepham, B., 2011. Food additives: an ethical evaluation. Br. Med. Bull., 99: 7-23.
Pagana, K., T. Pagana and T. Pagana, 2019. Mosby's Diagnostic and Laboratory Test Reference. 14th Edn., Elsevier, United States Pages: 1088.
Harrington, S., 2008. The role of sugar-sweetened beverage consumption in adolescent obesity: A review of the literature. J. School Nur., 24: 3-12.
Schulze, M.B., S. Liu, E.B. Rimm, J.E. Manson, W.C. Willett and F.B. Hu, 2004. Glycemic index, glycemic load and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women. Am. J. Clin. Nut., 80: 348-356.
Ighodaro, O.M., A.M. Adeosun, O. Fuyi-Williams, F. Ojiko and A.T. Akorede, 2018. Time course effect of selected carbonated soft drinks on human fasting blood glucose level. Am. J. Res. Med. Sci., 3: 22-26.
Kahn, B.B. and J.S. Flier, 2000. Obesity and insulin resistance. J. Clin. Invest., 106: 473-481.
Bray, G.A., S.J. Nielsen and B.M. Popkin, 2004. Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity. Am. J. Clin. Nutr., 79: 537-543.
Tappy, L. and K.A. Le, 2010. Metabolic effects of fructose and the worldwide increase in obesity. Physiol. Rev., 90: 23-46.
Shi, X., W. Xue, S. Liang, J. Zhao and X. Zhang, 2016. Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutr. J., Vol. 15.
Qurrat-ul-Ain, S.A. Khan, 2015. Artificial sweeteners: safe or unsafe. J. Pak. Med. Assoc., 65: 225-227.
Bloomer, R.J., S.A. Peel, R.G. Moran and J.J, MacDonnchadh, 2016. Blood glucose and insulin response to artificially- and sugar-sweetened sodas in healthy men. Integr. Food. Nutr. Metab., 3: 268-272.
Toora, B.D., S. Seema, M. Manju and S. Mishra, 2018. Effect of artificial sweeteners on the blood glucose concentration. J. Med. Academics, 1: 81-85.
Mathur, K., R.K. Agrawal, S. Nagpure and D. Deshpande, 2020. Effect of artificial sweeteners on insulin resistance among type-2 diabetes mellitus patients. J. Fam. Med. Primary Care, 9: 69-71.
Keijzers, G.B., B.E.D. Galan, C.J. Tack and P. Smits, 2020. Caffeine can decrease insulin sensitivity in humans. Diabetes Care, 25: 364-369.
Rix, I., C. Nexøe-Larsen and N.C. Bergmann, 2000. Glucagon Physiology. In: Endotext, Feingold, K.R., B. Anawalt and A. Boyce (Eds.). MDText.com, Inc .
Sun, S.Z. and M.W. Empie, 2012. Fructose metabolism in humans – what isotopic tracer studies tell us. Nutr. Metab., Vol. 9, No. 89.
Spencer, M., A. Gupta, L.V. Dam, C. Shannon, S. Menees and W.D. Chey, 2016. Artificial sweeteners: A systematic review and primer for gastroenterologists. J. Neurogastroenterology Motil., 22: 168-180.
Whitehouse, C.R., J. Boullata and L.A. McCauley, 2008. The potential toxicity of artificial sweeteners. Aaohn J., 56: 251-261.
Hughes, J.A., N.X. West, D.M. Parker, M.H.v.d. Braak and M. Addy, 2000. Effects of pH and concentration of citric, malic and lactic acids on enamel, In vitro. J. Dentist., 28: 147-152.
Barbour, M.E., D.M. Parker, G.C. Allen and K.D. Jandt, 2003. Human enamel dissolution in citric acid as a function of pH in the range 2.30≤pH≤6.30 – a nanoindentation study. Eur. J. Oral. Sci., 111: 258-262.
Rajeev, G., A.J. Lewis and N. Srikant, 2020. A time based objective evaluation of the erosive effects of various beverages on enamel and cementum of deciduous and permanent teeth. J. Clin. Exp. Dent., Vol. 12, No. 1.
Chen, L., R. Liu, Y. Zhao and Z. Shi, 2020. High consumption of soft drinks is associated with an increased risk of fracture: A 7-year follow-up study. Nutrients, Vol. 12, No. 2.
Mazariegos-Ramos, E., F. Guerrero-Romero, M. RodrÃguez-Morán, R. Paniagua and D. Amato, 1995. Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in children: A case-control study. J. Pediatr., 126: 940-942.
Fernando, G.R., R.M. Martha and R. Evangelina, 1999. Consumption of soft drinks with phosphoric acid as a risk factor for the development of hypocalcemia in postmenopausal women. J. Clin. Epidemiol., 52: 1007-1010.
Richards, G. and A. Smith, 2015. Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children. J. Psychopharmacol., 29: 1236-1247.
Gaskins, A.J., J.W. Rich-Edwards, P.L. Williams, T.L. Toth, S.A. Missmer and J.E. Chavarro, 2018. Pre-pregnancy caffeine and caffeinated beverage intake and risk of spontaneous abortion. Eur. J. Nutr., 57: 107-117.
Gonzálezâ€DomÃnguez, R., R.M. Mateos, A.M. Lechugaâ€Sancho, J.J. Gonzálezâ€Cortés and M. Corralesâ€Cuevas et al., 2017. Synergic effects of sugar and caffeine on insulinâ€mediated metabolomic alterations after an acute consumption of soft drinks. Electrophoresis, 38: 2313-2322.
Partridge, D., K.A. Lloyd, J.M. Rhodes, A.W. Walker, A.M. Johnstone and B.J. Campbell, 2019. Food additives: Assessing the impact of exposure to permitted emulsifiers on bowel and metabolic health-introducing the FADiets study. Nutr. Bull., 44: 329-349.
Lennerz, B.S., S.B. Vafai, N.F. Delaney, C.B. Clish and A.A. Deik et al., 2015. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol. Genet. Metab., 114: 73-79.
Shahmohammadi, M., M. Javadi and M. Nassiri-Asl, 2016. An overview on the effects of sodium benzoate as a preservative in food products. Biotechnol. Health Sci., Vol. 3, No. 3.
Linke, B.G.O., T.A.C. Casagrande and L.A.C. Cardoso, 2018. Food additives and their health effects: A review on preservative sodium benzoate. Afr. J. Biotechnol., 17: 306-310.
Inetianbor, J.E., J.M. Yakubu and S.C. Ezeonu, 2015. Effects of food additives and preservatives on man- a review. Asian J. Sci. Technol., 6: 1118-1135.
Mirza, S.K., 2018. Study of harmful effects of consuming food additives and public awareness. Int. J. Sci. Res. Sci. Technol., 4: 1071-1074.
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