Effect of Dietary Habits on Serum Zinc Level in Patients with Inflammatory Bowel Disease During Remission Phase
Authors
- Ruaa E. Alabd Al Zeweya Primary Health Care Center, Baghdad, Iraq
-
Hayder G. Oufi
College of Pharmacy, Al-Turath University, Baghdad, Iraq
- Nawal Mehdi Firhan Alkhalidi GIT Teaching Hospital Medical City, Baghdad, Iraq
DOI:
https://doi.org/10.3923/pjn.2024.73.80Keywords:
Crohn’s disease, diet, dietary pattern, ulcerative colitis, zincAbstract
Background and Objective: In ulcerative colitis and Crohn’s disease, low zinc levels can worsen gastrointestinal symptoms. However, there is ongoing debate regarding zinc levels in individuals with Inflammatory Bowel Disease (IBD). The aim of this study was to investigate the relationship between dietary habits and serum zinc levels in patients with Inflammatory Bowel Disease (IBD) during remission and to identify potential factors contributing to zinc deficiency in this population. Materials and Methods: A retrospective cohort study was conducted at two hospitals, including 60 patients with IBD and 30 healthy controls. All participants completed a dietary questionnaire and serum zinc levels were measured. Results: Patients with Crohn’s disease and ulcerative colitis had significantly lower serum zinc levels compared to the control group. Regression analysis identified two significant determinants of lower zinc levels: being female and having any form of IBD. Conclusion: The study found that female sex and the presence of any form of IBD were associated with lower serum zinc levels. Dietary intake did not significantly influence zinc levels. It may be crucial to monitor zinc levels in IBD patients, particularly women, for proper management.
References
Alkhouri, R.H., H. Hashmi, R.D. Baker, D. Gelfond and S.S. Baker, 2012. Vitamin and mineral status in patients with inflammatory bowel disease. J. Pediatr. Gastroenterol. Nutr., 56: 89-92.
Appleyard, C.B., G. Hernández and C.F. RÃos-Bedoya, 2004. Basic epidemiology of inflammatory bowel disease in Puerto Rico. Inflammatory Bowel Dis., 10: 106-111.
Arnaud, J., M. Touvier, P. Galan, M. Andriollo-Sanchez and D. Ruffieux et al., 2010. Determinants of serum zinc concentrations in a population of French middle-age subjects (SU.VI.MAX cohort). Eur. J. Clin. Nutr., 64: 1057-1064.
Bao, S., M.J. Liu, B. Lee, B. Besecker, J.P. Lai, D.C. Guttridge and D.L. Knoell, 2010. Zinc modulates the innate immune response in vivo to polymicrobial sepsis through regulation of NF-κB. AJP-Lung Physiol., 298: 744-754.
Bernstein, C.N., S. Singh, L.A. Graff, J.R. Walker, N. Miller and M. Cheang, 2010. A prospective population-based study of triggers of symptomatic flares in IBD. Am. J. Gastroenterol., 105: 1994-2002.
Bonaventura, P., G. Benedetti, F. Albarède and P. Miossec, 2014. Zinc and its role in immunity and inflammation. Autoimmunity Rev., 14: 277-285.
Buxaderas, S.C. and R. Farre-Rovira, 1985. Whole blood and serum zinc levels in relation to sex and age. Revista Espanola Fisiologia, 41: 463-470.
Cohen, A.B., D. Lee, M.D. Long, M.D. Kappelman, C.F. Martin, R.S. Sandler and J.D. Lewis, 2012. Dietary patterns and self-reported associations of diet with symptoms of inflammatory bowel disease. Digestive Dis. Sci., 58: 1322-1328.
Sherbini, N., A.E. Shazly, S.A. Elhady, G.E. Mashad and J. Sabry, 2015. Effect of zinc supplementation on body mass index and serum levels of zinc and leptin in pediatric hemodialysis patients. Int. J. Nephrology Renovascular Dis., Vol. 8.
Filippi, J., R. Al-Jaouni, J.B. Wiroth, X. Hébuterne and S.M. Schneider, 2006. Nutritional deficiencies in patients with Crohn's disease in remission. Inflammatory Bowel Dis., 12: 185-191.
van Gennep, S., N.K.H. de Boer, M.E. Gielen, S.T. Rietdijk and K.B. Gecse et al., 2020. Impaired quality of working life in inflammatory bowel disease patients. Digestive Dis. Sci., 66: 2916-2924.
GÅ‚Ä…bska, D., A. Staniec and D. Guzek, 2018. Assessment of validity and reproducibility of the zinc-specific dietary intake questionnaire conducted for young Polish female respondents. Nutrients, Vol. 10.
Hendricks, K.M. and W.A. Walker, 1988. Zinc deficiency in inflammatory bowel disease. Nutr. Rev., 46: 401-408.
Hou, J.K., B. Abraham and H. El-Serag, 2011. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am. J. Gastroenterol., 106: 563-573.
Jackson, M.J., 1989. Physiology of Zinc: General Aspects. In: Zinc in Human Biology, Mills, C.F., (Ed.). Springer, New York, pp: 1-14.
Janssen, I., S.B. Heymsfield, Z. Wang and R. Ross, 2017. Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr. J. Applied Physiol., 89: 81-88.
Kaliora, A.C., 2023. Nutrition in inflammatory bowel diseases; Is there a role? Best Pract. & Res. Clin. Gastroenterol., Vol. 62-63.
Kaneko, S., J. Morino, S. Minato, K. Yanai and Y. Mutsuyoshi et al., 2020. Serum zinc concentration correlates with ferritin concentration in patients undergoing peritoneal dialysis: A cross-sectional study. Front. Med., Vol. 7.
Kiela, P.R. and F.K. Ghishan, 2016. Physiology of intestinal absorption and secretion. Best Pract. Res. Clin. Gastroenterol., 30: 145-159.
Krebs, N.F., 2018. Overview of zinc absorption and excretion in the human gastrointestinal tract. J. Nutr., 130: 1374S-1377S.
McClain, C., C. Soutor and L. Zieve, 1980. Zinc deficiency: A complication of Crohn's disease. Gastroenterology, 78: 272-279.
Michielan, A. and R. D’Incà , 2015. Intestinal permeability in inflammatory bowel disease: Pathogenesis, clinical evaluation, and therapy of leaky gut. Mediators Inflammation, Vol. 2015.
Mohammadi, E., D. Qujeq, H. Taheri and K. Hajian-Tilaki, 2016. Evaluation of serum trace element levels and superoxide dismutase activity in patients with inflammatory bowel disease: Translating basic research into clinical application. Bio. Trace Elem. Res., 177: 235-240.
Mullin, G.E., L.E. Matarese and M. Palmer, 2011. Gastrointestinal and Liver Disease Nutrition Desk Reference. 1st Edn., CRC Press, Boca Raton, ISBN: 9780429130465, Pages: 506.
Williet, N., H. Sarter, C. Gower-Rousseau, C. Adrianjafy and A. Olympie et al., 2016. Patient-reported outcomes in a French nationwide survey of inflammatory bowel disease patients. J. Crohn's Colitis, 11: 165-174.
Prasad, A.S., 2014. Zinc: An antioxidant and anti-inflammatory agent: Role of zinc in degenerative disorders of aging. J. Trace Elem. Med. Biol., 28: 364-371.
Radziszewska, M., J. Smarkusz-Zarzecka, L. Ostrowska and D. Pogodziński, 2022. Nutrition and supplementation in ulcerative colitis. Nutrients, Vol. 14.
Ruangritchankul, S., C. Sumananusorn, J. Sirivarasai, W. Monsuwan and P. Sritara, 2023. Association between dietary zinc intake, serum zinc level and multiple comorbidities in older adults. Nutrients, Vol. 15.
Shamir, R., M. Phillip and A. Levine, 2007. Growth retardation in pediatric crohn's disease. Inflammatory Bowel Dis., 13: 620-628.
Nishiuchi, M., T. Tsuchiya, A. Kadowaki, T. Goto, H. Shirakawa and M. Komai, 2017. Relationship between serum zinc level and the preference for spicy foods in healthy subjects. Biomed. Res. Trace Ele., 27: 162-168.
Sipos, F., 2014. Contribution of TLR signaling to the pathogenesis of colitis-associated cancer in inflammatory bowel disease. World J. Gastroenterol., 20: 12713-12721.
Zupo, R., A. Sila, F. Castellana, R. Bringiotti and M. Curlo et al., 2022. Prevalence of zinc deficiency in inflammatory bowel disease: a systematic review and meta-analysis. Nutrients, Vol. 14.
Wong, C.P., N.A. Rinaldi and E. Ho, 2015. Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation. Mol. Nutr. & Food Res., 59: 991-999.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
