Investigation and Biological Activity of Some Nonpolar Iron Amino Acid Chelates

Abstract

The nonpolar Fe (III) phenylalanine and glycine chelates have been synthesized and characterized by using different tools, in particular; elemental analysis, molar conductance, infrared and electron paramagnetic resonance spectra. The elemental analysis showed the formation of 1:3 [M: L] ratio. The molar conductance measurements revealed a non-electrolytic nature. The infrared spectral data displayed the complexation behavior which takes place through the nitrogen and oxygen atoms of the present amino acids. The electron paramagnetic resonance data showed the existence of an octahedral geometry structure. Thirty-eight adult rats divided into four groups; group I: included 10 rats received 0.5 mL physiological saline, group II: included 9 rats received 0.5 mg ferrous fumarate/kg body weight, group III: included 9 rats received 0.5 mg Iron phenylalanine chelate/kg body weight/day, group IV: included 10 rats received 0.5 mg Iron glycine chelate/kg body weight/day. All rats were killed then blood, serum samples and liver homogenate were obtained, in blood were measured Hb and HCT.