Protective Role of Ethanolic Extract of Vernonia amygdalina Against Potassium Bromate Induced Tissue Damage in Wistar Rats

Authors

  • S.J. Josiah Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria
  • S.C.O. Nwangwu Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria
  • A.A. Akintola Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University Okada, Edo State,
  • U. Usunobun Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria
  • F.S. Oyefule Department of Biochemistry, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria
  • O.K. Ajeigbe Department of Physiology, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria
  • A. Akinola Department of Physiology, School of Basic Medical Sciences, Igbinedion University Okada, Edo State, Nigeria

DOI:

https://doi.org/10.3923/pjn.2012.54.57

Keywords:

Malondialdehyde, potassium bromate, tissue damage, Vernonia amygdalina

Abstract

The protective role of ethanolic extract of Vernonia amygadalina against potassium bromate induced tissue damage in Wistar rats was investigated. Twenty rats were divided into four groups of five rats each (A, B, C and D). Group A was administered 1 ml of 0.25 M sucrose solution. Group C and D were pretreated with 250 mg/kg and 500 mg/kg body weight of the aqueous extract of V. amygdalina respectively. The oral induction of 60 mg/kg potassium bromate to groups B, C and D were done eight hours before sacrifice. The liver, spleen, brain, kidney, heart and stomach were collected. Organ-body weight ratio, total tissue protein, amino acid level and malondialdehyde level in the tissues were estimated. The result showed a significant increase in all the parameters studied in group B. The organ to body weight ratio, total protein level, MDA concentration significantly lowered at both doses and amino acid level reduction is significant (p<0.05) in Group C when compared with Group B. This suggested that ethanolic extract of Vernonia amygdalina has a protective potential against tissue damage induced by potassium bromate.

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Published

15.12.2011

Issue

Vol. 11 No. 1 (2012)

Section

Research Article

License

Copyright (c) 2012 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Josiah, S., Nwangwu, S., Akintola, A., Usunobun, U., Oyefule, F., Ajeigbe, O., & Akinola, A. (2011). Protective Role of Ethanolic Extract of Vernonia amygdalina Against Potassium Bromate Induced Tissue Damage in Wistar Rats. Pakistan Journal of Nutrition, 11(1), 54–57. https://doi.org/10.3923/pjn.2012.54.57