Plasma Lipid Profile in Sickle Cell Disease Patients in Owerri, Nigeria

Abstract

This study was done to determine the plasma lipid profile in sickle cell anaemia patients. Sixty eight sickle cell anemia (HbSS) patients aged 15-35 years were used for the study. A total of seventy healthy volunteers with HbAA genotype aged 15-35 years were used as control. The plasma cholesterol (119.7±18.4 mg/dl) in sickle cell anemia were significantly decreased (p<0.05) when compared with the control (171.4±21.2 mg/dl). Also the plasma high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol in sickle cell anaemia (40.3±10.5 mg/dl and 51.3±2.1 mg/dl) were significantly decreased (p<0.05) when compared with the control (67.9±14.4 mg/dl and 81.7±2.7 mg/dl). There is no significant variation in the mean level of triglyceride in sickle cell disease when compared with the control. This result shows that sickle cell disease patients are not prone to coronary heart disease.