Research Article Open Access

Vitamin D Deficiency and Hematological Parameters in People Living with HIV/AIDS

Authors

Juli Yosa Mega
Master Program in Tropical Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, North Sumatera, Indonesia
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Elrica
Master Program in Tropical Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, North Sumatera, Indonesia
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CORRESPONDING AUTHOR
Dina Keumala Sari
Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, North Sumatera, Indonesia
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Dewi Indah Sari Siregar
Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan 20155, North Sumatera, Indonesia
Published on: April 15, 2020
DOI 10.3923/pjn.2020.217.224
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Abstract

Background and Objective: Patients with Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) infection experiences deficiency of vitamin D and abnormality of hematological parameters related to inflammatory and thrombotic activities. This study was designed to determine the relationship between changes in hematological parameters and vitamin D in HIV/AIDS infection. Materials and Methods: A cross-sectional study was conducted on 70 HIV/AIDS patients consuming Efavirenz (EFV)-based Antiretroviral Therapy (ART) for less than 6 months. Parameters including 25-hydroxy-vitamin D [25(OH)D] level and complete blood count. All parameters were measured in the Special Treatment Center (Pusat Pelayanan Khusus, Pusyansus) of the Voluntary Counseling and Testing (VCT) Clinic at Rumah Sakit Umum Pusat (RSUP) Haji Adam Malik, Medan, Indonesia. Results: There was a significant difference in terms of platelet count [mean±standard deviation: 329531.25 (79175.99) μL–1 vs 282710.53 (69895.25) μL–1, p = 0.011], Mean Platelet Volume/Platelet count (MPV/PLT) [Median (Interquartile Range): 2.86×10–5 (1.70×10–5-5.06×10–5) vs 3.27×10–5 (1.94×10–5-10.0×10–5), p = 0.022] and plateletcrit (PCT) [mean±standard deviation: 0.29 (0.08)% vs 0.25 (0.06)%, p = 0.018] in the group with 25(OH)D level of <21 ng mL–1 compared to the group with 25(OH)D level of ≥21 ng mL–1. There was a significant difference in terms of platelet count between the vitamin D sufficiency and insufficiency groups [mean±standard deviation: 300166.67 (71387.33) μL–1 vs 274653.85 (69095.84) μL–1, p = 0.036]. A significant difference was found in terms of platelet distribution width (PDW) between the vitamin D deficiency and insufficiency groups [mean±standard deviation: 9.02 (1.14)% vs 9.48 (1.03)%, p = 0.020]. Conclusion: Low level of vitamin D significantly correlated with platelet index in HIV/AIDS patients consuming EFV-based ART.

Keywords:

25-hydroxyvitamin D, complete blood count, deficiency, HIV/AIDS

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Mega, J. Y., Elrica, Sari, D. K., & Siregar, D. I. S. (2020). Vitamin D Deficiency and Hematological Parameters in People Living with HIV/AIDS. Pakistan Journal of Nutrition, 19(5), 217–224. https://doi.org/10.3923/pjn.2020.217.224
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