Effects of Aqueous Extract of Triplochiton scleroxylon on White Blood Cell Differentials in Alloxan-Induced Diabetic Rabbits

Authors

  • T.P. Prohp Department of Medical Biochemistry, College of Health Sciences, Faculty of Basic Medicine, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria
  • L.C. Anyanwu Departments of Anatomy, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • S.C. Uzoaru Department of Medical Laboratory Sciences, Ebonyi State University, Abakiliki, Ebonyi State, Nigeria
  • P.C. Onyebuagu Departments of Physiology, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • N. Obeto Departments of Physiology, College of Medicine, Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • I.O. Onoagbe Department of Biochemistry, University of Benin, Benin City, Edo State, Nigeria

DOI:

https://doi.org/10.3923/pjn.2008.258.261

Keywords:

Alloxan-induced, Triplochiton scleroxylon, white blood cell

Abstract

Studies were conducted on the effects of aqueous extract of Triplochiton scleroxylon on white blood cell differentials in alloxan-induced diabetic rabbits. At least 100 mL of the aqueous extract was administered orally to test rabbits of New Zealand strain weighing between 1200 to 1680g for a period of 28 days. Clean drinking troughs were used in the administration of water and aqueous extract to the control and test rabbits respectively. Blood was collected for analyses intravenously through the larger vein at the back of the ear of rabbits. Hematological Swelab autocounter 920E+ (UK) was used in the determination of white blood cell differentials; neutrophils, lymphocytes, basophils and eosinophils. Analyses of results showed that the aqueous extract of the bark of Triplochiton scleroxylon did not have significant effects (p>0.05) on white blood cell differentials in alloxan-induced diabetic rabbits studied. Plasma glucose concentration decreased significantly (p<0.05) on the 18th, 24th and 28th days of administration of aqueous bark extract of this plant. Triplochiton scleroxylon has hypoglycemic and anti-diabetic properties and the aqueous bark extract may not predispose to white blood cell dysfunctions.

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Published

15.02.2008

Issue

Vol. 7 No. 2 (2008)

Section

Research Article

License

Copyright (c) 2008 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Prohp, T., Anyanwu, L., Uzoaru, S., Onyebuagu, P., Obeto, N., & Onoagbe, I. (2008). Effects of Aqueous Extract of Triplochiton scleroxylon on White Blood Cell Differentials in Alloxan-Induced Diabetic Rabbits. Pakistan Journal of Nutrition, 7(2), 258–261. https://doi.org/10.3923/pjn.2008.258.261

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