Effect of a Nigerian Type Diet on Indices of Cell Proliferation

Authors

  • A. Osagie Department of Medical Biochemistry, College of Medicine, Ambrose Alli University, Ekpoma, Nigeria
  • G. Eriyamremu Department of Biochemistry, University of Benin, Benin City, Edo State, Nigeria
  • T.P. Prohp Department of Medical Biochemistry, College of Health Sciences, Niger Delta University, Bayelsa State, Nigeria

DOI:

https://doi.org/10.3923/pjn.2008.262.265

Keywords:

Albino rats, cell proliferation, Nigerian type diet

Abstract

The effect of a Nigerian type diet on indices of cell proliferation in albino rats administered cycads was examined. Rats of wister strain weighing between 80.0g and 79.7g were used in the experiment. These rats were assigned to four experimental groups and respectively exposed to a Nigerian type diet for a period of five weeks. The rats were sacrificed at the end of the experiment and the colon separated for analysis. A significantly low feed intake was observed in the Normal Diet (ND) fed rats compared to the other groups. No significant alteration (p>0.05) was observed in weight gain in all the experimental groups. When compared with the controls, the ATPase activity (total ATPase, Na+/K+ ATPase, Mg2+ ATPase and Ca2+ ATPase) of both colonic mucosa and tissue were not significantly different (p>0.05) in total lipid and total phospholipids of both the colonic mucosa and tissue in all the experimental groups. A Nigerian type diet may therefore have a protective role against colon cancer in rats fed with cycads at least within the first five weeks.

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Published

15.02.2008

Issue

Section

Research Article

How to Cite

1.
Osagie A, Eriyamremu G, Prohp T. Effect of a Nigerian Type Diet on Indices of Cell Proliferation. Pak. J. Nutr. [Internet]. 2008 Feb. 15 [cited 2025 Jul. 8];7(2):262–265. Available from: https://pjnonline.org/pjn/article/view/629

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