Study of Dietary Supplement with Compound Proteins on the Improvement of Nutrition of Dialysis Patients
DOI:
https://doi.org/10.3923/pjn.2015.353.357Keywords:
Chronic renal disease, chronic renal failure, dialysis, nutritional supplementAbstract
The study aims to investigate the effect of a liquid supplement UNECE U-99 on the nutritional status of patients receiving maintenance dialysis. For this purpose, 47 participants (27 males and 20 females), aged 29 to 82 (average: 60), who underwent maintenance dialysis were recruited to the study. Two participants were excluded from the analysis as one was unwell for the study and the other was transferred to another hospital. Remaining 45 participants (25 males and 20 females) to be included in the final analysis. The participants were given 4 weeks of UNECE U-99 supplementation. The nutritional evaluation, biochemical tests and anti-oxidant capacity measurements were performed before and after the intervention. After 4 weeks of UNECE U-99, dietary energy intake and uptake of protein, fat and carbohydrate were significantly increased. Plasma albumin levels were elevated (p<0.01). A significant increase in anti-oxidant capacity was also observed. Calcium levels were increased (p<0.05) whereas potassium levels were reduced (p<0.01). Post-dialysis creatinine levels at week 4 compared to the baseline were decreased (p<0.01) and uric acid levels at week 4 were also reduced. It is concluded that UNECE U-99, a nutritional supplement designed for dialysis patients improved their nutritional status in this short term study.
References
De Aguilar-Nascimento, J.E., B.R.P. Silveira and D.B. Dock-Nascimento, 2011. Early enteral nutrition with whey protein or casein in elderly patients with acute ischemic stroke: A double-blind randomized trial. Nutrition, 27: 440-444.
Chen, Y.C., H.H. Chen and J.C. Yeh, 1999. Postdialysis serum albumin is more rational than predialysis value. Nephron, 82: 284-285.
Erdman, Jr.J.W., 2000. AHA science advisory: Soy protein and cardiovascular disease. A statement for healthcare professionals from the nutrition committee of the AHA. Circulation, 102: 2555-2559.
Feldman, L., M. Shani, I. Sinuani, I. Beberashvili and J. Weissgarten, 2012. N‐acetylcysteine may improve residual renal function in hemodialysis patients: A pilot study. Hemodial. Int., 16: 512-516.
Fouque, D., K. Kalantar-Zadeh, J. Kopple, N. Cano and P. Chauveau et al., 2008. A proposed nomenclature and diagnostic criteria for protein-energy wasting in acute and chronic kidney disease. Kidney Int., 73: 391-398.
Fouque, D., J. McKenzie, R. de Mutsert, R. Azar and D. Teta et al., 2008. Use of a renal-specific oral supplement by haemodialysis patients with low protein intake does not increase the need for phosphate binders and may prevent a decline in nutritional status and quality of life. Nephrol. Dialysis Transplant., 23: 2902-2910.
Galland, R., J. Traeger, W. Arkouche, C. Cleaud, E. Delawari and D. Fouque, 2001. Short daily hemodialysis rapidly improves nutritional status in hemodialysis patients. Kidney Int., 60: 1555-1560.
Giray, B., E. Kan, M. Bali, F. Hincal and N. Basaran, 2003. The effect of vitamin E supplementation on antioxidant enzyme activities and lipid peroxidation levels in hemodialysis patients. Clin. Chim. Acta, 338: 91-98.
Huang, J., B. Yi, A.M. Li and H. Zhang, 2015. Effects of vitamin E-coated dialysis membranes on anemia, nutrition and dyslipidemia status in hemodialysis patients: A meta-analysis. Renal Failure, 37: 398-407.
Kalantar-Zadeh, K., A. Braglia, J. Chow, O. Kwon and N. Kuwae et al., 2005. An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: A pilot/feasibility study. J. Renal Nutr., 15: 318-331.
Kopple, J.D., 1999. Pathophysiology of protein-energy wasting in chronic renal failure. J. Nutr., 129: 247S-251S.
Lines, S.W., A.M. Carter, E.J. Dunn, E.J. Lindley, J.E. Tattersall and M.J. Wright, 2014. A randomized controlled trial evaluating the erythropoiesis stimulating agent sparing potential of a vitamin E-bonded polysulfone dialysis membrane. Nephrol. Dial. Transplant., 29: 649-656.
Locatelli, F., B. Canaud, K.U. Eckardt, P. Stenvinkel, C. Wanner and C. Zoccali, 2003. Oxidative stress in end‐stage renal disease: An emerging threat to patient outcome. Nephrol. Dial. Transplant., 18: 1272-1280.
Locatelli, F., D. Fouque, O. Heimburger, T.B. Drueke, J.B. Cannata‐Andia, W.H. Horl and E. Ritz, 2002. Nutritional status in dialysis patients: A European consensus. Nephrol. Dial. Transplant., 17: 563-572.
Locatelli, F., C. Manzoni, L. Del Vecchio and S. di Filippo, 1998. Changes in the clinical condition of haemodialysis patients. J. Nephrol., 12: S82-S91.
Marshall, K., 2004. Therapeutic applications of whey protein. Altern. Med. Rev., 9: 136-156.
Reynolds, K., A. Chin, K.A. Lees, A. Nguyen, D. Bujnowski and J. He, 2006. A meta-analysis of the effect of soy protein supplementation on serum lipids. Am. J. Cardiol., 98: 633-640.
Sezer, S., Z. Bal, E. Tutal, M.E. Uyar and N.O. Acar, 2014. Long-term oral nutrition supplementation improves outcomes in malnourished patients with chronic kidney disease on hemodialysis. J. Parenteral Enteral Nutr., 38: 960-965.
Zhang, K., Y. Li, X. Cheng, L. Liu and W. Bai et al., 2013. Cross-over study of influence of oral vitamin C supplementation on inflammatory status in maintenance hemodialysis patients. BMC Nephrol., Vol. 14.
Downloads
Published
Issue
Section
License
Copyright (c) 2015 Asian Network for Scientific Information
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
