Correlation Between Matrix Metalloproteinase 8 in Gingival Crevicular Fluid and Zinc Consumption
DOI:
https://doi.org/10.3923/pjn.2016.72.75Keywords:
Matrix Metalloproteinase-8, periodontal disease, zincAbstract
Gingivitis is a disease affecting the gingival tissues, when the gingivitis is not properly treated, it will lead to a destructive of periodontal tissue structure. Periodontitis can cause periodontal tissue destruction and loss of the dental arch, further facial abnormalities and gastrointestinal disorder. Zinc is Matrix Metalloproteinase-8 cofactor. This study aims to prove the relationship between levels of Matrix Metalloproteinase-8 of the Gingival Crevicular Fluid (GCF) and zinc consumption of the Minangkabaunese in West Sumatera, Indonesia. This study involved 60 subjects, consisted of 20 healthy subjects, 20 patients of mild gingivitis and 20 patients of mild periodontitis. Matrix Metalloproteinase-8 level was tested by using ELISA method. Consumption of zinc was measured by using Minangkabau Food Frequency Questionnaire (FFQ). Data analysis was performed by means of univariate to describe each variable. Kolmogorov Smirnof Test was used to analyze normal distribution. Pearson correlation was applied to correlate between Matrix Metalloproteinase-8 level and zinc consumption. This study concluded that there was a significant correlation between the levels of matrix metalloprotease-8 and zinc consumption. Relationship between Matrix Metalloproteinase-8 and zinc consumption showed a strong correlation with negative direction (r = -0.865). Supplementation of zinc maybe used as a treatment for periodontal inflammation.
References
Amaleinei, C., I.R. Caruntu and R.A. Balan, 2007. Biology of Metalloproteases and remodelling. Romanian J. Morphol. Embriol., 48: 323-334.
Apajalahti, S., 2004. Short Root Anomaly (SRA) prevalence and phenotypic features in families: With emphasis on matrix metalloproteinases in gingival crevicular fluid of SRA and orthodontic patients. Institute of Dentistry Department of Pedodontics and Orthodontics, University of Helsinky, Finland.
O-Charoenrat, P., P.H. Rhys-Evans and S.A. Eccles, 2001. Expression of matrix metalloproteinases and their inhibitors correlates with invasion and metastasis in squamous cell carcinoma of the head and neck. Arch. Otolaryngol. Head Neck Surg., 127: 813-820.
Chung, L., D. Dinakarpandian, N. Yoshida, J.L. Lauer-Fields, G.B. Fields, R. Visse and H. Nagase, 2004. Collagenase unwinds triple-helical collagen prior to peptide bond hydrolysis. EMBO J., 23: 3020-3030.
Cox, H.J. and C.M. Overall, 2008. Cytokine Substrates: MMP Regulation of Inflammatory Signaling Molecules. In: The Cancer Degradome: Proteases and Cancer Biology, Edwars, D., G. Hoyer-Hansen, F. Blasi and B.F. Sloane (Eds.). Chapter 26, Spinger, New York, USA., ISBN: 978-0-387-69056-8, pp: 519-539.
Fehrenbach, M.J. and J. Weiner, 2009. Review of Dental Hygiene. 2nd Edn., Elsevier Science Health Science Division, St. Louis, MI., USA., ISBN: 9781437706406, Pages: 622.
Kinane, D.F., I.B. Darby, S. Said, H. Luoto, T. Sorsa, S. Tikanoja and P. Mantyla, 2003. Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance. J. Periodontal Res., 38: 400-404.
Norppa, A., 2012. Association between periodontal and systemic inflammation: A study of pro- and anti-inflammatory mediators. Acta Universitatis Ouluensis D Medica 1180, Oulu, Finland. http://jultika.oulu.fi/files/isbn9789514299681.pdf.
Nagase, H., R. Visse and G. Murphy, 2006. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res., 69: 562-573.
Overbeck, S., L. Rink and H. Haase, 2008. Modulating the immune response by oral zinc supplementation: A single approach for multiple diseases. Arch. Immunol. Ther. Exp., 56: 15-30.
Prasad, A.S., 2008. Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp. Gerontol., 43: 370-377.
Perinetti, G., M. Paolantonio, B. Femminella, E. Serra and G. Spoto, 2008. Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients. J. Periodontol., 79: 1200-1207.
Socransky, S.S. and A.D. Haffajee, 2005. Periodontal microbial ecology. Periodontology 2000, 38: 135-187.
Sorsa, T., L. Tjaderhane, Y.T. Konttinen, A. Lauhio and T. Salo et al., 2006. Matrix metalloproteinases: Contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann. Med., 38: 306-321.
Verma, R.P. and C. Hansch, 2007. Matrix Metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs. Bioorg. Med. Chem., 15: 2223-2268.
Whittaker, M., C.D. Floyd, P. Brown and A.J.H. Gearing, 1999. Design and therapeutic application of matrix metalloproteinase inhibitors. Chem. Rev., 99: 2735-2776.
Zaverio, M.R. and P.J. Shaun, 2002. Platelet Trombus Formation in Flowing Blood. In: Platelets, Michelson, A.D. (Ed.). Academic Press, London, pp: 404.
Downloads
Published
Issue
Section
License
Copyright (c) 2016 Asian Network for Scientific Information
This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
