Research Article Open Access

Vitamin D Status in Patients with Type 2 Diabetes Mellitus in Makkah Region of Saudi Arabia

Authors

CORRESPONDING AUTHOR
I.R. Dabbour
Department of Nutrition and Food Technology, Faculty of Agriculture, Mutah University, AlKarak, P.O. Box 61710, Jordan
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A.S. Jazar
Department of Clinical Nutrition, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah, Saudi Arabia
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F.S. Azzeh
Department of Clinical Nutrition, Faculty of Applied Medical Science, Umm Al-Qura University, Makkah, Saudi Arabia
Published on: February 15, 2016
DOI 10.3923/pjn.2016.203.210
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Abstract

Deficiency of vitamin D is still a worldwide health problem. Although the sun is replete all over the year in Saudi Arabia, it has been shown that deficiency of vitamin D is an important health problem. The aim of this study was to investigate the association of serum 25-hydroxy vitamin D [25(OH)-D] in type 2 diabetic patients (T2DM) compared to control healthy subjects. A randomized case-control study was conducted and a total of 200 subjects were equally categorized in each group. A detailed basic information questionnaire was used. Serum levels of 25(OH)-D and others related biochemical analysis were also measured. According to our results, there were no significant differences (p>0.05) in age, serum 25(OH)-D level, parathyroid hormone (PTH), alkaline phosphatase (ALP) and BMI between case and control groups. On the other hand, there was a significant inverse relationship between age and serum 25(OH)-D level (r = -0.37, p<0.05), while a significant positive correlation between serum 25(OH)-D and intakes of vitamin D (r = 0.33, p<0.05) was observed. The mean value of serum 25(OH)-D was significantly higher (p<0.05) for the subjects who regularly played outdoor physical activities than those subjects who did not play regularly. Respect of income, the mean value of serum 25(OH)-D for subjects with low income was significantly (p<0.05) higher than those subjects with high income. Additionally, the mean value of serum 25(OH)-D for subjects who can write and read was significantly (p<0.05) higher than those illiterate subjects and subjects hold a university degree. The mean value of serum 25(OH)-D level for small family size was significantly (p<0.05) higher than those with large family size. The subjects in our study were generally deficient in 25(OH)-D irrespective of having T2DM, indicating a greater need for vitamin D supplementation.

Keywords:

Parathyroid hormone, physical activity, type 2 diabetes mellitus, vitamin D

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Dabbour, I., Jazar, A., & Azzeh, F. (2016). Vitamin D Status in Patients with Type 2 Diabetes Mellitus in Makkah Region of Saudi Arabia. Pakistan Journal of Nutrition, 15(3), 203–210. https://doi.org/10.3923/pjn.2016.203.210
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References

1.
Al-Daghri, N., O. Al-Attas, M. Alokail, K. Alkharfy and M. Yousef et al., 2010. Hypovitaminosis D and cardiometabolic risk factors among non-obese youth. Open Med., 5: 752-757.
2.
AlHumaidi, M., A. Agha and M. Dewish, 2013. Vitamin D deficiency in patients with type-2 diabetes mellitus in Southern region of Saudi Arabia. Maedica, 8: 231-236.
3.
Alqurashi, K.A., K.S. Aljabri and S.A. Bokhari, 2011. Prevalence of diabetes mellitus in a Saudi community. Ann. Saudi Med., 31: 19-23.
4.
Al-Turki, H., M. Sadat-Ali, A. Al-Elq, F.A. Al-Mulhim and A.K. Al-Ali, 2008. 25-Hydoxyvitamin D levels among healthy Saudi Arabian women. Saudi Med. J., 29: 1765-1768.
5.
Ardawi, M.S., M.H. Qari, A.A. Rouzi, A.A. Maimani and R.M. Raddadi, 2011. Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre-and postmenopausal women. Osteoporosis Int., 22: 463-475.
6.
Ardawi, M.S.M., A.M. Sibiany, T.M. Bakhsh, M.H. Qari and A.A. Maimani, 2012. High prevalence of vitamin D deficiency among healthy Saudi Arabian men: relationship to bone mineral density, parathyroid hormone, bone turnover markers and lifestyle factors. Osteoporosis Int., 23: 675-686.
7.
Azzeh, F.S., 2012. Relationship between vitamin D and rheumatoid arthritis disease. Pak. J. Nutr., 11: 293-300.
8.
Azzeh, F.S. and O.A. Kensara, 2015. Vitamin D is a good marker for disease activity of rheumatoid arthritis disease. Dis. Markers, Vol. 2015.
9.
Barchetta, I., F. Angelico, M.D. Ben, M.G. Baroni, P. Pozzilli, S. Morini and M.G. Cavallo, 2011. Strong association between Non Alcoholic Fatty Liver Disease (NAFLD) and low 25 (OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med., Vol. 9.
10.
Baroncelli, G.l., A. Bereket, M. El-Kholy, L. Audi and Y. Cesur et al., 2008. Rickets in the Middle East: Role of environment and genetic predisposition. J. Clin. Endocrinol. Metab., 93: 1743-1750.
11.
Bierschenk, L., J. Alexander, C. Wasserfall, M. Haller, D. Schatz and M. Atkinson, 2009. Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment. Diabetes Care, 32: 1977-1979.
12.
Brock, K., W.Y. Huang, D.R. Fraser, L. Ke and M. Tseng et al., 2010. Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women. J. Steroid Biochem. Mol. Biol., 121: 462-466.
13.
Gordon, C.M., K.C. DePeter, H.A. Feldman, E. Grace, S.J. Emans, 2004. Prevalence of vitamin D deficiency among healthy adolescents. Arch. Pediatr. Adolesc. Med., 158: 531-537.
14.
CDoSI., 2012. Household expenditure and income survey, Saudi Arabia. Central Department of Statistics and Information, Saudi Arabia.
15.
Deleskog, A., A. Hilding, K. Brismar, A. Hamsten, S. Efendic and C.G. Ostenson, 2012. Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance. Diabetologia, 55: 1668-1678.
16.
NIH., 1997. Vitamin D. In: Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. NIH. (Ed.). National Academy Press, Washington, DC., USA., pp: 250-287.
17.
Fuleihan, G.E.H., M. Nabulsi, M. Choucair, M. Salamoun, C.H. Shahine, A. Kizirian and R. Tannous, 2001. Hypovitaminosis D in healthy schoolchildren. Pediatrics, Vol. 107.
18.
Gordon, K.D., P.G. Perez-Gonzalez, K.A. Misselt, E.J. Murphy and G.J. Bendo et al., 2004. Spatially resolved ultraviolet, Hα, infrared and radio star formation in M81. Astrophys. J. Supplement Ser., Vol. 154.
19.
Holick, M.F., 2007. Vitamin D deficiency. N. Engl. J. Med., 357: 266-281.
20.
Holick, M.F., 2004. Vitamin D: Importance in the prevention of cancers, type 1 diabetes, heart disease and osteoporosis. Am. J. Clin. Nutr., 79: 362-371.
21.
Holick, M.F., 2004. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers and cardiovascular disease. Am. J. Clin. Nutr., 80: 1678S-1688S.
22.
Holick, M.F., 2006. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin. Proc., 81: 353-373.
23.
Hypponen, E. and C. Power, 2007. Hypovitaminosis D in British adults at age 45 y: Nationwide cohort study of dietary and lifestyle predictors. Am. J. Clin. Nutr., 85: 860-868.
24.
Kamycheva, E., R.M. Joakimsen and R. Jorde, 2003. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J. Nutr., 133: 102-106.
25.
Kensarah, O.A. and F.S. Azzeh, 2012. Vitamin D status of healthy school children from Western Saudi Arabia. Pak. J. Nutr., 11: 288-292.
26.
Kensarah, O., A. Jazar and F. Azzeh, 2015. Hypovitaminosis D in healthy toddlers and preschool children from Western Saudi Arabia. Int. J. Vitamin Nutr. Res., 85: 50-60.
27.
Mathieu, C., C. Gysemans, A. Giulietti and R. Bouillon, 2005. Vitamin D and diabetes. Diabetologia, 48: 1247-1257.
28.
Misra, M., D. Pacaud, A. Petryk, P.F. Collett-Solberg and M. Kappy, 2008. Vitamin D deficiency in children and its management: Review of current knowledge and recommendations. Pediatrics, 122: 398-417.
29.
NIH, 2008. Dietary supplement fact sheet: Vitamin D. Maryland, USA. National Institutes of Health, http://ods.od.nih.gov/factsheets/ VitaminD-Consumer/.
30.
Nesby-O'Dell, S., K.S. Scanlon, M.E. Cogswell, C. Gillespie and B.W. Hollis et al., 2002. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age: Third National Health and Nutrition Examination Survey, 1988-1994. Am. J. Clin. Nutr., 76: 187-192.
31.
Nicolaidou, P., Z. Hatzistamatiou, A. Papadopoulou, J. Kaleyias and E. Floropoulou et al., 2006. Low vitamin D status in mother-newborn pairs in Greece. Calcified Tiss. Int., 78: 337-342.
32.
Nikooyeh, B., T.R. Neyestani, M. Farvid, H. Alavi-Majd and A. Houshiarrad et al., 2011. Daily consumption of vitamin D-or vitamin D+ calcium-fortified yogurt drink improved glycemic control in patients with type 2 diabetes: A randomized clinical trial. Am. J. Clin. Nutr., 93: 764-771.
33.
Pellett, P.L. and S. Shadarevian, 1970. Food Composition: Tables for Use in the Middle East. 2nd Edn., American University of Beirut, Lebanon, Pages: 116.
34.
Pietschmann, P., G. Schernthaner and W. Woloszczuk, 1988. Serum osteocalcin levels in diabetes mellitus: Analysis of the type of diabetes and microvascular complications. Diabetologia, 31: 892-895.
35.
Racinais, S., B. Hamilton, C.K. Li and J. Grantham, 2010. Vitamin D and physical fitness in Qatari girls. Arch. Dis. Childhood, 95: 854-855.
36.
Rolfes, S., K. Pinna and E. Whitney, 2009. Understanding Normal and Clinical Nutrition. Cengage Learning, USA., Pages: 382.
37.
Sadat-Ali, M., A. Al-Elq, H. Al-Turki, F. Al-Mulhim and A. Al-Ali, 2009. Vitamin D levels among healthy Saudi Arabian men. Ann. Saudi Med., 29: 378-382.
38.
Scragg, R., I. Holdaway, V. Singh, P. Metcalf, J. Baker and E. Dryson, 1995. Serum 25-hydroxyvitamin D3 is related to physical activity and ethnicity but not obesity in a multicultural workforce. Aust. N. Z. J. Med., 25: 218-223.
39.
Scragg, R. and C.A. Camargo, Jr., 2008. Scragg and camargo respond to Am. J. Epidemiol., 168: 590-591.
40.
Snijder, M.B., R.M. van Dam, M. Visser, D.J.H. Deeg and J.M. Dekker et al., 2005. Adiposity in relation to vitamin D status and parathyroid hormone levels: A population-based study in older men and women. J. Clin. Endocrinol. Metab., 90: 4119-4123.
41.
Taheri, E., A. Saedisomeolia, M. Djalali, M. Qorbani and M.M. Civi, 2012. The relationship between serum 25-hydroxy vitamin D concentration and obesity in type 2 diabetic patients and healthy subjects. J. Diabetes Metabolic Disorders, Vol. 11.
42.
Vimaleswaran, K.S., D.J. Berry, C. Lu, E. Tikkanen and S. Pilz et al., 2013. Causal relationship between obesity and vitamin D status: Bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med., Vol. 10.
43.
WHO., 2013. Diabetes. World Health Organization, Geneva, Switzerland.