Research Article Open Access

Fiber Increases Endogenous Insulin and Reduces Insulin Resistance in Diabetes

Authors

CORRESPONDING AUTHOR
Sunarti
Department of Biochemistry, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
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Sri Lestari Sulistyo Rini
Department of Physiology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
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Dianandha Septiana Rubi
Department of Biochemistry, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia
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Miftakhussolikhah
Research Center for Natural Product Technology, Lembaga Ilmu Pengetahuan Indonesia (LIPI), Gading Playen, Gunungkidul, Yogyakarta 55861, Indonesia
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Dini Ariani
Research Center for Natural Product Technology, Lembaga Ilmu Pengetahuan Indonesia (LIPI), Gading Playen, Gunungkidul, Yogyakarta 55861, Indonesia
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Hemi Sinorita
Department of Internal Medicine, Central Hospital Dr. Sardjito, Yogyakarta 55281, Indonesia
Published on: August 15, 2019
DOI 10.3923/pjn.2019.895.899
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Abstract

Background and Objective: Dietary fibers have been identified to have beneficial effects in improving insulin secretion and insulin resistance. This study aimed to evaluate the effects of fiber-rich snacks on insulin secretion and insulin resistance in patients with type 2 diabetes mellitus (T2DM). Materials and Methods: Twenty patients with T2DM, ages 40-60 years were recruited from the Polyclinic of Endocrine, General Hospital Dr. Sardjito, Yogyakarta, Indonesia. The subjects received daily 32 g snacks made from a mixture of Dioscorea esculenta, arrowroot, cassava and pumpkin, for 4 weeks. Fasting plasma glucose, insulin and C-peptide levels were measured before and after intervention. Paired t-tests were used to evaluate the results. Results: Intervention of fiber-rich snacks for 4 weeks for T2DM patients significantly (p = 0.01) reduced fasting plasma glucose from 9.3±2.7 to 8.3±2.5 mmol L–1 and homeostatic model assessment of insulin resistance (p = 0.04) from 4.1±1.3 to 3.6±1.9 and significantly (p<0.001) increased C-peptide levels from 0.417±0.004 to 0.512±0.008 ng mL–1. Conclusion: In this study, fiber-rich snacks provide significant benefits to increase endogenous insulin secretion and reduce insulin resistance in patients with T2DM.

Keywords:

Body mass index, dietary fiber, HOMA-IR, insulin resistance index, lipid profile, snack supplement, T2DM

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This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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How to Cite

Sunarti, Rini, S. L. S., Rubi, D. S., Miftakhussolikhah, Ariani, D., & Sinorita, H. (2019). Fiber Increases Endogenous Insulin and Reduces Insulin Resistance in Diabetes. Pakistan Journal of Nutrition, 18(9), 895–899. https://doi.org/10.3923/pjn.2019.895.899
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References

1.
Saini, V., 2010. Molecular mechanisms of insulin resistance in type 2 diabetes mellitus. World J. Diabetes, 1: 68-75.
2.
Adam, K.M., S. Tajelsir and D.A. Aowad, 2016. Correlation between C-Peptide level and chronic microvascular complications in type 2 diabetes mellitus sudanese patients. Open Access Library J., 3: 1-7.
3.
Jones, A.G. and A.T. Hattersley, 2013. The clinical utility of C-peptide measurement in the care of patients with diabetes. Diabetic Med., 30: 803-817.
4.
Banu, S., R.N. Jabir, N.C. Manjunath, S. Shakil and A.M. Kamal, 2011. C-peptide and its correlation to parameters of insulin resistance in the metabolic syndrome. CNS Neurol. Disorders-Drug Targets, 10: 921-927.
5.
Yanai, H. and Y. Hirowatari, 2017. Fasting serum C-peptide levels (> 1.6 ng/mL) can predict the presence of insulin resistance in Japanese patients with type 2 diabetes. Diabetes Metab., 1: 97-98.
6.
Bernardino, C., K.C. McLellan, J.E. Corrente and R.C. Burini, 2016. Carbohydrate intake and dietary fiber ratio as diagnostic tool for diet quality and prognostics of insulin resistance in Brazilian free-living adults. Int. J. Food Sci. Nutr. Dietetics, 5: 319-324.
7.
Chen, C., Y. Zeng, J. Xu, H. Zheng and J. Liu et al., 2016. Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus. Exp. Ther. Med., 12: 1232-1242.
8.
Wheeler, M.L., S.A. Dunbar, L.M. Jaacks, W. Karmally, E.J. Mayer-Davis, J. Wylie-Rosett and W.S. Yancy, 2012. Macronutrients, food groups and eating patterns in the management of diabetes: A systematic review of the literature, 2010. Diabetes Care, 35: 434-445.
9.
Rokka, S., E. Ketoja, E. Järvenpää and R. Tahvonen, 2013. The glycaemic and C-peptide responses of foods rich in dietary fibre from oat, buckwheat and lingonberry. Int. J. Food Sci. Nutr., 64: 528-534.
10.
Bodinham, C.L., L. Smith, J. Wright, G.S. Frost and M.D. Robertson, 2012. Dietary fibre improves first-phase insulin secretion in overweight individuals. PLoS One, Vol. 7, No. 7.
11.
Ray, S., A.K. Bairagi, S. Guha, S. Ganguly, D. Ray, A.K. Basu and A. Sinha, 2012. A simple way to identify insulin resistance in non-diabetic acute coronary syndrome patients with impaired fasting glucose. Indian J. Endocrinol. Metab., 16: S460-S464.
12.
Kumalasari, I.K., E. Harmayani, L.A. Lestari, S. Raharjo, W. Asmara, K. Nishi and T. Sugahara, 2012. Evaluation of immunostimulatory effect of the arrowroot (Maranta arundinacea L.) in vitro and in vivo. Cytotechnology, 64: 131-137.
13.
Li, Y.O. and A.R. Komarek, 2017. Dietary fibre basics: Health, nutrition, analysis and applications. Food Qual. Saf., 1: 47-59.
14.
Lattimer, J.M. and M.D. Haub, 2010. Effects of dietary fiber and its components on metabolic health. Nutrients, 2: 1266-1289.
15.
Müller, M., E.E. Canfora and E.E. Blaak, 2018. Gastrointestinal transit time, glucose homeostasis and metabolic health: Modulation by dietary fibers. Nutrients, Vol. 10, No. 3.
16.
Li, C. and M. Uppal, 2010. Canadian diabetes association national nutrition committee clinical update on dietary fibre in diabetes: Food sources to physiological effects. Can. J. Diabetes, 34: 355-361.
17.
Byrne, C.S., E.S. Chambers, D.J. Morrison and G. Frost, 2015. The role of short chain fatty acids in appetite regulation and energy homeostasis. Int. J. Obesity, 39: 1331-1338.
18.
Ma, M. and T. Mu, 2016. Anti-diabetic effects of soluble and insoluble dietary ï¬bre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats. J. Funct. Foods 25: 186-196.
19.
Sardá, F.A.H., E.B. Giuntini, M.L.P.A. Gomez, M.C.Y. Lui and J.A.E. Negrini et al., 2016. Impact of resistant starch from unripe banana flour on hunger, satiety, and glucose homeostasis in healthy volunteers. J. Funct. Foods, 24: 63-74.
20.
Bindels, L.B., R.R.S. Munoz, J.C. Gomes-Neto, V. Mutemberezi and I. Martinez et al., 2017. Resistant starch can improve insulin sensitivity independently of the gut microbiota. Microbiome, Vol. 5.
21.
Khan, H.A., S.H. Sobki, A. Ekhzaimy, I. Khan and M.A. Almusawi, 2018. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi J. Biol. Sci., 25: 1729-1732.
22.
Leighton, M., C.A.R. Sainsbury and G.C. Jones, 2004. A practical review of C-peptide testing in diabetes. Diabetes Ther., 8: 475-487.
23.
Wahren, J., J. Shafqat, J. Johansson, A. Chibalin, K. Ekberg and H. Jörnvall, 2004. Molecular and cellular effects of C-peptide-new perspectives on an old peptide. Exp. Diabetes Res., 5: 15-23.
24.
Sultania, S., D. Thakur and M. Kulshreshtha, 2017. Study of lipid profile in type 2 diabetes mellitus patients and its correlation with HbA1c. Int. J. Contemp. Med. Res., 4: 437-439.
25.
Rai, S., K. Prajna and T. Rai, 2018. Lipid profile in type 2 diabetes mellitus and in diabetic nephropathy. Int. J. Clin. Biochem. Res., 4: 379-382.

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