Influence of Black Cumin Fixed and Essential Oil Supplementation on Markers of Myocardial Necrosis in Normal and Diabetic Rats

Abstract

The cardiovascular disorders are major cause of mortality in diabetic patients and myocardial necrosis, atherosclerosis and high blood pressure are major ailments in this regard. The core objective of the present research study was to explore the role of Black Cumin Seed Fixed Oil (BCFO) and Black Cumin Essential Oil (BCEO) on the markers of myocardial necrosis i.e. cardiac enzymes in normal and diabetic Sprague dawley rats. Diabetes mellitus was induced using streptozotocin @ 60 mg/Kg body weight. The three diets were prepared i.e. D₁ (control), D₂ (BCFO @ 4.0%) and D₃ (BCEO @ 0.30%) and added separately in the diets and fed to the respective groups for a period of 56 days. The results indicated that diets were insignificant and level of cardiac enzymes remained in the safe ranges in normal rats. However, diabetes affected deleteriously and markers of myocardial necrosis increased in control group. In comparison, BCFO and BCEO normalized the levels of markers of myocardial necrosis. However, BCEO was more effective in reduced the elevated levels of these enzymes. Moreover, increased levels of transferases in diabetic rats were also reduced as a function of BCFO and BCEO treatment. In the nutshell, it can be assumed that black cumin essential oil is more effective in reducing the elevated levels of enzymes thus reducing the onset of cardiovascular disorders in diabetes mellitus.